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Human AFT1 Protein expressed in Escherichia coli (E. coli) - ABIN668009
Gupta, Prywes: ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression. in The Journal of biological chemistry 2002
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genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved.
EWSR1 (show EWSR1 Proteins)-ATF1 fusion gene was found in hyalinizing clear cell carcinoma
Heme activates the ATF1 pathway in human macrophages via AMPK (show PRKAA1 Proteins), and that a similar response occurs after treatment of cells with metformin.
ATF1 protein expression was significantly lower in colorectal cancer tissues than corresponding normal tissues; patients with higher ATF1 expression levels have a significantly higher survival rate than those with lower expression
Review: discuss clinicopathologic and molecular features of group of neoplasms unified by the presence of EWSR1 (show EWSR1 Proteins)-CREB1 (show CREB1 Proteins) and EWSR1 (show EWSR1 Proteins)-ATF1 genetic fusions.
ATF-1 mediates HO-1 (show HMOX1 Proteins) induction by heme and drives macrophage adaptation to intraplaque hemorrhage.
Hyalinizing clear-cell carcinoma is a unique low-grade salivary carcinoma that consistently harbors EWSR1 (show EWSR1 Proteins)-ATF1 fusion.
Differential expression of CREB (show CREB1 Proteins)/ATF transcription factors could be observed on neurogenic induction, pointing to a decisive role of the cAMP-CREB (show CREB1 Proteins)/ATF system.
An increase in phosphorylation of CREB (show CREB1 Proteins)/ATF-1 in human dental pulp cells was noted after exposure to PGF2alpha for 1-20 min,with a maximal induction at 10 min.
DNA cytosine methylation in the bovine leukemia virus promoter has a role in direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator (show CREM Proteins)/activation transcription factor binding
the HSF1 (show HSF1 Proteins) complex, including BRG1 (show SMARCA4 Proteins) and lysine acetyltransferases p300 (show NOTCH1 Proteins) and CREB-binding protein (CBP (show CREBBP Proteins)), is formed in a manner dependent on the phosphorylation of ATF1
conclude that HO-1 (show HMOX1 Proteins) regulates DC maturation and function by modulating the p38 MAPK (show MAPK14 Proteins)-CREB (show CREB1 Proteins)/ATF1 signaling axis
Dehydroepiandrosterone sulfate (DHEAS (show SULT2A1 Proteins))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (show GPR34 Proteins), since silencing of Gnalpha11 leads to the abolition of the DHEAS (show SULT2A1 Proteins)-induced stimulation of Erk1/2, ATF-1, and CREB (show CREB1 Proteins).
indicate that dysregulation of p38 MAPK (show MAPK14 Proteins)-CREB (show CREB1 Proteins)/ATF1 signaling axis underlies the altered function and phenotype in Nrf2 (show NFE2L2 Proteins)-deficient DCs
Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation.
miR (show MLXIP Proteins)-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis.
ATF1 is a novel substrate of RSK2 (show RPS6KA3 Proteins) and that RSK2 (show RPS6KA3 Proteins)-ATF1 signaling plays an important role in EGF (show EGF Proteins)-induced neoplastic cell transformation.
study demonstrates a role for trophic signaling and constitutive activation of activating transcription factor 1(Atf1) and cAMP response element-binding protein (CREB) at the time of zygotic genome activation
MSK1 (show RPS6KA5 Proteins) and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB (show CREB1 Proteins) and ATF1 in fibroblasts.
phosphorylation by the ERK MAPK (show MAPK1 Proteins) pathway is required for epidermal growth factor (show EGF Proteins)-induced c-jun (show JUN Proteins) expression
Data indicate increasing expression for CREB (show CREB1 Proteins), ATF1, and ATF3 (show ATF3 Proteins) during gastrulation.
This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.
activating transcription factor 1
, cyclic AMP-dependent transcription factor ATF-1
, cAMP-dependent transcription factor ATF-1