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Browse our AFT1 Proteins (AFT1)

Full name:
Activating Transcription Factor 1 Proteins (AFT1)
On are 13 Activating Transcription Factor 1 (AFT1) Proteins from 6 different suppliers available. Additionally we are shipping AFT1 Antibodies (137) and AFT1 Kits (37) and many more products for this protein. A total of 201 AFT1 products are currently listed.
Atf-1, ATF1, EWS-ATF1, FUS/ATF-1, TREB36, wu:fc92c07, zgc:64099
list all proteins Gene Name GeneID UniProt
AFT1 466 P18846
AFT1 11908 P81269
AFT1 315305  

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AFT1 Proteins (AFT1) by Origin

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Top referenced AFT1 Proteins

  1. Human AFT1 Protein expressed in Escherichia coli (E. coli) - ABIN668009 : Gupta, Prywes: ATF1 phosphorylation by the ERK MAPK pathway is required for epidermal growth factor-induced c-jun expression. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN668009

More Proteins for AFT1 Interaction Partners

Human Activating Transcription Factor 1 (AFT1) interaction partners

  1. genetic association studies in a population in China: Data suggest that an SNP in ATF1 (rs11169571) is associated with essential hypertension in the population studied; altered binding of microRNA-1283 appears to be involved.

  2. EWSR1 (show EWSR1 Proteins)-ATF1 fusion gene was found in hyalinizing clear cell carcinoma

  3. Heme activates the ATF1 pathway in human macrophages via AMPK (show PRKAA1 Proteins), and that a similar response occurs after treatment of cells with metformin.

  4. ATF1 protein expression was significantly lower in colorectal cancer tissues than corresponding normal tissues; patients with higher ATF1 expression levels have a significantly higher survival rate than those with lower expression

  5. Review: discuss clinicopathologic and molecular features of group of neoplasms unified by the presence of EWSR1 (show EWSR1 Proteins)-CREB1 (show CREB1 Proteins) and EWSR1 (show EWSR1 Proteins)-ATF1 genetic fusions.

  6. ATF-1 mediates HO-1 (show HMOX1 Proteins) induction by heme and drives macrophage adaptation to intraplaque hemorrhage.

  7. Hyalinizing clear-cell carcinoma is a unique low-grade salivary carcinoma that consistently harbors EWSR1 (show EWSR1 Proteins)-ATF1 fusion.

  8. Differential expression of CREB (show CREB1 Proteins)/ATF transcription factors could be observed on neurogenic induction, pointing to a decisive role of the cAMP-CREB (show CREB1 Proteins)/ATF system.

  9. An increase in phosphorylation of CREB (show CREB1 Proteins)/ATF-1 in human dental pulp cells was noted after exposure to PGF2alpha for 1-20 min,with a maximal induction at 10 min.

  10. DNA cytosine methylation in the bovine leukemia virus promoter has a role in direct inhibition of cAMP-responsive element (CRE)-binding protein/CRE modulator (show CREM Proteins)/activation transcription factor binding

Mouse (Murine) Activating Transcription Factor 1 (AFT1) interaction partners

  1. the HSF1 (show HSF1 Proteins) complex, including BRG1 (show SMARCA4 Proteins) and lysine acetyltransferases p300 (show NOTCH1 Proteins) and CREB-binding protein (CBP (show CREBBP Proteins)), is formed in a manner dependent on the phosphorylation of ATF1

  2. conclude that HO-1 (show HMOX1 Proteins) regulates DC maturation and function by modulating the p38 MAPK (show MAPK14 Proteins)-CREB (show CREB1 Proteins)/ATF1 signaling axis

  3. Dehydroepiandrosterone sulfate (DHEAS (show SULT2A1 Proteins))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (show GPR34 Proteins), since silencing of Gnalpha11 leads to the abolition of the DHEAS (show SULT2A1 Proteins)-induced stimulation of Erk1/2, ATF-1, and CREB (show CREB1 Proteins).

  4. indicate that dysregulation of p38 MAPK (show MAPK14 Proteins)-CREB (show CREB1 Proteins)/ATF1 signaling axis underlies the altered function and phenotype in Nrf2 (show NFE2L2 Proteins)-deficient DCs

  5. Forced expression of EWS/ATF1 resulted in the development of EWS/ATF1-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1-driven transformation.

  6. miR (show MLXIP Proteins)-34c functions, at least partially, by targeting the ATF1 gene in germ cell apoptosis, providing a novel mechanism with involvement of miRNA in the regulation of germ cell apoptosis.

  7. ATF1 is a novel substrate of RSK2 (show RPS6KA3 Proteins) and that RSK2 (show RPS6KA3 Proteins)-ATF1 signaling plays an important role in EGF (show EGF Proteins)-induced neoplastic cell transformation.

  8. study demonstrates a role for trophic signaling and constitutive activation of activating transcription factor 1(Atf1) and cAMP response element-binding protein (CREB) at the time of zygotic genome activation

  9. MSK1 (show RPS6KA5 Proteins) and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB (show CREB1 Proteins) and ATF1 in fibroblasts.

  10. phosphorylation by the ERK MAPK (show MAPK1 Proteins) pathway is required for epidermal growth factor (show EGF Proteins)-induced c-jun (show JUN Proteins) expression

Rabbit Activating Transcription Factor 1 (AFT1) interaction partners

  1. Data indicate increasing expression for CREB (show CREB1 Proteins), ATF1, and ATF3 (show ATF3 Proteins) during gastrulation.

AFT1 Protein Profile

Protein Summary

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.

Alternative names and synonyms associated with AFT1

  • activating transcription factor 1 (atf1)
  • activating transcription factor 1 (ATF1)
  • activating transcription factor 1 (MGC85066)
  • activating transcription factor 1 (Atf1)
  • activating transcription factor 1 (LOC100340999)
  • Atf-1 protein
  • ATF1 protein
  • EWS-ATF1 protein
  • FUS/ATF-1 protein
  • TREB36 protein
  • wu:fc92c07 protein
  • zgc:64099 protein

Protein level used designations for AFT1

activating transcription factor 1 , cyclic AMP-dependent transcription factor ATF-1 , cAMP-dependent transcription factor ATF-1 , TCR-ATF1

448303 Xenopus (Silurana) tropicalis
452429 Pan troglodytes
693644 Macaca mulatta
779184 Xenopus laevis
466 Homo sapiens
496344 Xenopus laevis
486545 Canis lupus familiaris
506967 Bos taurus
11908 Mus musculus
315305 Rattus norvegicus
325609 Danio rerio
100340999 Oryctolagus cuniculus
100719533 Cavia porcellus
426873 Gallus gallus
101117917 Ovis aries
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