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Data suggest that the interaction between PCBP2 (show PCBP2 Proteins) and the 3'UTR of the ARHGDIA mRNA may induce a local change in RNA structure that favors subsequent binding of miR (show MLXIP Proteins)-151-5p and miR-16 (show GDE1 Proteins), thus leading to the suppression of ARHGDIA expression.
our results suggest that RhoGDIalpha regulate TRF1 (show TERF1 Proteins) and telomere length and may be novel prognostic biomarkers in colorectal cancer
Together, our results suggest a role for Ly-GDI (show ARHGDIB Proteins) in the localized regulation of Rho GTPases in platelets and hypothesize a link between the PKC (show PRRT2 Proteins) and Rho GTPase (show RACGAP1 Proteins) signaling systems in platelet function.
MiR (show MLXIP Proteins)-25 is activated by the WNT (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway, and exerts its pro-metastatic function by directly inhibiting the Rho GDP dissociation inhibitor alpha (RhoGDI1). Downregulation of RhoGDI1 enhances expression of Snail (show SNAI1 Proteins), thereby promoting EMT (show ITK Proteins).
RIP2 and RhoGDI bind to p75(NTR (show NGFR Proteins)) death domain at partially overlapping epitopes with over 100-fold difference in affinity, revealing the mechanism by which RIP2 recruitment displaces RhoGDI upon ligand binding.
Downregulation of RhoGDI could be a critical mechanism of breast tumor development, which may involve the hyperactivation of Rho GTPases and upregulation of COX-2 activity.
RHOGDI alpha acetylation interferes with Rho signaling, resulting in alteration of cellular filamentous actin.
the present study has identified loss of ARHGDIA contributed to the processes of hepatic tumorigenesis, in particular invasion and metastasis
new mechanistic insights into the understanding of essential role of SUMOylation at Lys (show LYZ Proteins)-138 in RhoGDIalpha's biological function.
By directly targeting the Rho GDP dissociation inhibitor alpha (RhoGDI1) and activated leukocyte cell adhesion molecule (ALCAM (show ALCAM Proteins)).
Increased expression of bovine Rho GDIalpha (show GDI1 Proteins) led to electrophysiological alterations that resulted in atrial arrhythmias and AV conduction abnormalities in transgenic mice, whereas ventricular contractile function was largely preserved.
that inhibition of Ca2 (show CA2 Proteins)+ channel activity by overexpression of Rho GDI-alpha is mediated by inhibition of RhoA (show RHOA Proteins) in cardiac myocytes
Rho GDP association inhibitor (GDI) alpha- mediated disruption of Rho GTPase (show RACGAP1 Proteins) activity impairs lens fiber cell migration, elongation and survival.
GDIalpha has a critical role in suppressing Rac1 activity in mature podocytes
Integrin beta 8 and PTP-PEST (show PTPN12 Proteins) form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 (show CDC42 Proteins) signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1.
RhoGDalpha controls ENaC expression and activity via Rac1.
the association of RhoGDIalpha with TROY (show TNFRSF19 Proteins) contributed to TROY (show TNFRSF19 Proteins)-dependent RhoA (show RHOA Proteins) activation and neurite outgrowth inhibition after Nogo (show RTN4 Proteins)-66 stimulation.
Data found that CCK (show CCK Proteins)-induced PKCalpha (show PKCa Proteins) phosphorylation on RhoGDI1 at Ser96 releases RhoA (show RHOA Proteins) and Rac1 from RhoGDI1 to facilitate Rho GTPases signaling.
we demonstrated the regulation of targeting/accumulation of the RhoGDIalpha-Rac1 complex to phagosomes
how the beta cell utilizes RhoGDI for differential Cdc42 and Rac1 cycling
Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation.
analysis of inhibitory and shuttling functions of rhoGDI-3 (show ARHGDIG Proteins) and rhoGDI-1
Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993
rho GDI 1
, rho GDP-dissociation inhibitor 1
, rho-GDI alpha
, Rho GDP dissociation inhibitor (GDI) alpha
, Rho GDI alpha