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Human Monoclonal ARHGEF4 Primary Antibody for FACS, WB - ABIN2749042
Zhang, Chen, Gao, Lin, Zhu, Lu, Shi, Gao, Zhou, Xu, Zhang, Wu: Structural basis for the recognition of Asef by adenomatous polyposis coli. in Cell research 2012
Show all 3 references for ABIN2749042
Human Monoclonal ARHGEF4 Primary Antibody for FACS, WB - ABIN2749098
Lyons, Williams, Morrow, Sebire, Hubank, Anderson: The RAC specific guanine nucleotide exchange factor Asef functions downstream from TEL-AML1 to promote leukaemic transformation. in Leukemia research 2010
Show all 3 references for ABIN2749098
Human Polyclonal ARHGEF4 Primary Antibody for ELISA, WB - ABIN185088
Thiesen, Kübart, Ropers, Nothwang: Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22. in Biochemical and biophysical research communications 2000
These data demonstrate, that in addition to microtubule-independent Tiam1 (show TIAM1 Antibodies) activation, HGF (show HGF Antibodies) engages additional microtubule- and APC (show APC Antibodies)-dependent pathway of Asef activation.
these results demonstrate potent anti-inflammatory effects by HGF (show HGF Antibodies) and delineate a key role of Asef in the mediation of the HGF (show HGF Antibodies) barrier protective and anti-inflammatory effects.
Expression of Asef was associated with lower estimated glomerular filtration rate in kidney disease.
Expression of ARHGEF4 (Rho guanine nucleotide exchange factor 4) is restricted to the brain and may regulate the actin cytoskeletal network, cell morphology and migration, and neuronal function
structures thus elucidate the molecular mechanism of Asef recognition by APC (show APC Antibodies)
Forced expression of Asef in vitro induced and maintained proliferation of haemaopoietic progenitor cells and co-operated with TEL-AML1 greatly to enhance proliferation and haemopoietic colony size
Positive role of Tyr94 phosphorylation in EGF-induced Asef activation following the activation of Rac1.
Asef and APC (show APC Antibodies) function downstream of HGF (show HGF Antibodies) and PI3-kinase (show PIK3CA Antibodies), and play critical roles in growth factor-mediated regulation of cell morphology and migration
Asef has a role in HGF (show HGF Antibodies)-mediated protection against endothelial hyperpermeability and lung injury.
Asef and Asef2 (show SPATA13 Antibodies) are required for adenoma formation in Apc (show APC Antibodies)(Min/+)mice.
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.
Rho guanine nucleotide exchange factor (GEF) 4
, Rho guanine nucleotide exchange factor 4
, rho guanine nucleotide exchange factor 4
, rho guanine nucleotide exchange factor 4-like
, APC-stimulated guanine nucleotide exchange factor 1
, APC-stimulated guanine nucleotide exchange factor