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Browse our anti-ARHGEF6 (ARHGEF6) Antibodies

Full name:
anti-rho Guanine Nucleotide Exchange Factor (GEF) 6 Antibodies (ARHGEF6)
On are 35 rho Guanine Nucleotide Exchange Factor (GEF) 6 (ARHGEF6) Antibodies from 10 different suppliers available. Additionally we are shipping ARHGEF6 Proteins (4) and many more products for this protein. A total of 44 ARHGEF6 products are currently listed.
1600028C08Rik, 1700038J06Rik, 4930592P22Rik, alpha-PIX, alphaPIX, Cool-2, COOL2, MRX46, PIXA
list all antibodies Gene Name GeneID UniProt
ARHGEF6 9459 Q15052
ARHGEF6 73341 Q8K4I3
ARHGEF6 363509 Q5XXR3

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anti-Human ARHGEF6 Antibodies:

anti-Mouse (Murine) ARHGEF6 Antibodies:

anti-Rat (Rattus) ARHGEF6 Antibodies:

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Top referenced anti-ARHGEF6 Antibodies

  1. Human Polyclonal ARHGEF6 Primary Antibody for EIA, WB - ABIN950497 : Maiti: Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells. in The pharmacogenomics journal 2010 (PubMed)
    Show all 3 references for ABIN950497

  2. Human Polyclonal ARHGEF6 Primary Antibody for ICC, IF - ABIN4281559 : Kortüm, Harms, Hennighausen, Rosenberger: αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor. in PLoS ONE 2015 (PubMed)

More Antibodies against ARHGEF6 Interaction Partners

Human rho Guanine Nucleotide Exchange Factor (GEF) 6 (ARHGEF6) interaction partners

  1. show that ARHGEF6 is constitutively linked to GIT1, a GAP of Arf family small G proteins, and that ARHGEF6 phosphorylation enables binding of the 14-3-3 adaptor protein to the ARHGEF6/GIT1 complex

  2. The novel recycling regulator alpha-PIX and the degradation factor c-Cbl (show CBL Antibodies) closely cooperate in the regulation of EGFR (show EGFR Antibodies) trafficking.

  3. c-Cbl (show CBL Antibodies) negatively regulates alphaPix-mediated cell migration and invasion; the lack of c-Cbl (show CBL Antibodies) in C6 and A172 glioma cells is responsible for their malignant behavior

  4. results suggest that low doses of chlorambucil and very low doses of chronic oxidative stress together kill Cbl (show CBL Antibodies)-resistant ovarian carcinoma cells and ARHGEF6 signaling may have an instrumental role in induction of apoptosis in Cbl (show CBL Antibodies)(cos) cells.

  5. These findings suggest that alpha Pix plays an important role in mutant huntingtin (show HTT Antibodies) aggregation.

  6. The interaction of alphaPix with CagA (show S100A8 Antibodies) activates PAK1 (show PAK1 Antibodies), ERK (show EPHB2 Antibodies) and NF-kappaB (show NFKB1 Antibodies), which induces IL-8 (show IL8 Antibodies) expression in H. pylori-infected gastric epithelial cells.

  7. The plexin-B1 (show PLXNB1 Antibodies)/Rac (show AKT1 Antibodies) interaction inhibits PAK activation and enhances Sema4D (show SEMA4D Antibodies) ligand binding

  8. Expression of Cbl-b effectively blocks the ability of Cool-2 to stimulate PAK, providing an additional mechanism, aside from catalyzing receptor ubiquitination, by which Cbl-b acts as a negative regulator for signaling activities requiring PAK activation.

  9. Data suggest that Rac (show AKT1 Antibodies)-dependent activation of the NFkappaB (show NFKB1 Antibodies) pathway may be a critical element promoting thrombin (show F2 Antibodies)-induced tissue factor (show F3 Antibodies) expression and activity, and thus a prothrombotic state in pulmonary hypertension.

  10. Whereas alphaPIX guanine nucleotide exchange factor (show RASGRF1 Antibodies) activity contributes to enhanced formation of cellular protrusions, the GEF (show SLC2A4RG Antibodies)-independent association with calpain 4 (show CAPNS1 Antibodies) leads to induction of a yet unknown signaling cascade resulting in cell spreading.

Mouse (Murine) rho Guanine Nucleotide Exchange Factor (GEF) 6 (ARHGEF6) interaction partners

  1. Enforced expression of miR-135a in highly tumorigenic cancer stem cells strongly inhibited tumorigenesis by repressing the miR-135a direct target gene Arhgef6.

  2. Results indicate Arhgef6 (alphaPIX) as a regulator of thymocyte migration and subsequent arrest that is linked to positive selection.

  3. alphaPIX and GIT2 (show GIT2 Antibodies) are required for neuronal differentiation.

  4. suggest that imbalance in activity of different Rho GTPases may underlie altered neuronal connectivity and impaired synaptic function and cognition in alphaPix/Arhgef6 knockout mice

  5. The mouse Arhgef6 gene: cDNA sequence, expression analysis, and X chromosome assignment.

  6. ARHGEF6 is localized in dendritic spines where it contributes to regulate dendritic spine morphogenesis.

  7. These results reveal specific roles for alphaPIX in the immune system and suggest that redundancy with betaPIX (show ARHGEF7 Antibodies) precludes a more severe immune phenotype.

ARHGEF6 Antigen Profile

Antigen Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.

Alternative names and synonyms associated with ARHGEF6

  • Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 (ARHGEF6) antibody
  • Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 (Arhgef6) antibody
  • 1600028C08Rik antibody
  • 1700038J06Rik antibody
  • 4930592P22Rik antibody
  • alpha-PIX antibody
  • alphaPIX antibody
  • Cool-2 antibody
  • COOL2 antibody
  • MRX46 antibody
  • PIXA antibody

Protein level used designations for ARHGEF6

PAK-interacting exchange factor alpha , PAK-interacting exchange factor, alpha , Rac/Cdc42 guanine exchange factor (GEF) 6 , rac/Cdc42 guanine nucleotide exchange factor 6 , rho guanine nucleotide exchange factor 6 , alpha PIX Rho GTPase guanine nucleotide exchange factor , rac/cdc42 guanine nucleotide exchange factor 6

9459 Homo sapiens
73341 Mus musculus
363509 Rattus norvegicus
422247 Gallus gallus
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