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Browse our DDIT4 Proteins (DDIT4)

Full name:
DNA-Damage-Inducible Transcript 4 Proteins (DDIT4)
On www.antibodies-online.com are 13 DNA-Damage-Inducible Transcript 4 (DDIT4) Proteins from 6 different suppliers available. Additionally we are shipping DDIT4 Antibodies (89) and DDIT4 Kits (1) and many more products for this protein. A total of 113 DDIT4 products are currently listed.
Synonyms:
5830413E08Rik, AA415483, dig2, REDD-1, REDD1, rtp801, sb:cb821, zgc:64114
list all proteins Gene Name GeneID UniProt
DDIT4 54541 Q9NX09
DDIT4 74747 Q9D3F7
DDIT4 140942 Q8VHZ9

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DDIT4 Proteins (DDIT4) by Origin

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Top referenced DDIT4 Proteins

  1. Human DDIT4 Protein expressed in Escherichia coli (E. coli) - ABIN667871 : Regazzetti, Bost, Le Marchand-Brustel, Tanti, Giorgetti-Peraldi: Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes. in The Journal of biological chemistry 2010 (PubMed)
    Show all 2 references for ABIN667871

More Proteins for DDIT4 Interaction Partners

Human DNA-Damage-Inducible Transcript 4 (DDIT4) interaction partners

  1. The production of superoxide anion in nockout-Rtp801 mouse lung fibroblasts (MLF) was lower than that in Rtp801 Wt cells after cigarette smoke extract treatment, and it was inhibited in Wt MLF by silencing nicotinamide adenine dinucleotide phosphate oxidase (show DUOX2 Proteins)-4 (Nox4 (show NOX4 Proteins)) expression with small interfering Nox4 (show NOX4 Proteins) RNA.

  2. Changes in REDD1 mRNA and protein have been observed in skeletal muscle under various physiological conditions (e.g., nutrient consumption and resistance exercise) and pathological conditions (e.g., sepsis, alcoholism, diabetes, obesity) suggesting a role for REDD1 in regulating mTORC1-dependent skeletal muscle protein metabolism. [Review]

  3. a novel STAT3 (show STAT3 Proteins)-dependent mechanism of both IL-6 (show IL6 Proteins)-induced activation of mTOR (show FRAP1 Proteins) and IL-6 (show IL6 Proteins)-dependent reversion of stress-induced inhibition of mTOR (show FRAP1 Proteins) activity, is reported.

  4. findings implicate REDD1 as a crucial regulator of mTORC1 activity in iron-depleted cells

  5. C/EBPbeta (show CEBPB Proteins) promotes autophagy in PC3 (show PCSK1 Proteins) cells by augmenting REDD1 expression.

  6. These data highlight the central role of REDD1 in regulating both protein synthesis and autophagy in skeletal muscle during sepsis.

  7. Findings from this study propose a REDD1-regulated mechanism in T2D skeletal muscle that may contribute to whole body insulin (show INS Proteins) resistance and may be a target to improve insulin (show INS Proteins) action in insulin (show INS Proteins)-resistant individuals.

  8. REDD1 knockout (KO) mice, all skin compartments, epidermal stem, and progenitor cells were protected from atrophic effects of glucocorticoids.

  9. MiR (show MLXIP Proteins)-630 reduced apoptosis by downregulating several apoptotic modulators, PARP3 (show PARP3 Proteins), DDIT4, and EP300 (show EP300 Proteins).

  10. REDD1 and p-AKT (show AKT1 Proteins) over-expression may serve as a prognostic biomarker in ovarian cancer, but KRAS mutations and REDD1 protein over-expression were not correlated in OC.

Mouse (Murine) DNA-Damage-Inducible Transcript 4 (DDIT4) interaction partners

  1. These data suggest that loss of REDD1 augments the rate of the OV-induced increase in muscle mass by altering multiple protein balance pathways.

  2. The production of superoxide anion in nockout-Rtp801 mouse lung fibroblasts (MLF) was lower than that in Rtp801 Wt cells after cigarette smoke extract treatment, and it was inhibited in Wt MLF by silencing nicotinamide adenine dinucleotide phosphate oxidase (show DUOX1 Proteins)-4 (Nox4 (show NOX4 Proteins)) expression with small interfering Nox4 (show NOX4 Proteins) RNA.

  3. REDD1 is required for normal insulin (show INS Proteins)-stimulated signaling, and a subtle balance exists between MEK1 (show MAP2K1 Proteins)/2, REDD1, and mTOR (show FRAP1 Proteins)

  4. study suggests that VDR (show CYP27B1 Proteins) regulates Ddit4 expression during epidermal homeostasis and the wound healing process, while elevated Ddit4 represents an early growth-arresting stress response within VDR (show CYP27B1 Proteins)(-/-) follicles.

  5. REDD1 knockout T cells exhibit a defect in proliferation and cell survival, although markers of activation appear normal. These findings demonstrate a previously unappreciated role for REDD1 in T cell function.

  6. Reactive oxygen species regulation through REDD1/TXNIP (show TXNIP Proteins) is physiological rheostat controlling stress-induced autophagy.

  7. LPS (show TLR4 Proteins) induces REDD1 expression by two distinct CREB (show CREB1 Proteins)-mediated mechanisms

  8. Glucocorticoids induce skin atrophy and activate REDD1 expression.

  9. REDD1 expression limits the nutrient-induced stimulation of protein synthesis and activation of mTORC1 signaling during periods of feed deprivation.

  10. REDD1 is necessary for hyperglycemia mediated effects on VEGF expression in the retina of diabetic mice.

Zebrafish DNA-Damage-Inducible Transcript 4 (DDIT4) interaction partners

  1. Redd1 alters dorsoventral patterning by antagonizing the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway.

DDIT4 Protein Profile

Protein Summary

HIF-1-responsive gene that may protect some types of cells from hypoxia and H(2)O(2)-triggered apoptosis

Alternative names and synonyms associated with DDIT4

  • DNA-damage-inducible transcript 4 (ddit4)
  • DNA-damage-inducible transcript 4 (DDIT4)
  • DNA-damage-inducible transcript 4 (Ddit4)
  • 5830413E08Rik protein
  • AA415483 protein
  • dig2 protein
  • REDD-1 protein
  • REDD1 protein
  • rtp801 protein
  • sb:cb821 protein
  • zgc:64114 protein

Protein level used designations for DDIT4

DNA damage-inducible transcript 4 protein , REDD-1 , DNA-damage-inducible transcript 4 protein , protein regulated in development and DNA damage response 1 , DNA-damage-inducible transcript 4 , HIF-1 responsive protein RTP801 , HIF-1 responsive RTP801 , dexamethasone-induced gene 2 protein , regulated in development and DNA damage response 1

GENE ID SPECIES
394782 Xenopus (Silurana) tropicalis
450520 Pan troglodytes
489038 Canis lupus familiaris
54541 Homo sapiens
74747 Mus musculus
140942 Rattus norvegicus
100153821 Sus scrofa
529235 Bos taurus
379481 Xenopus laevis
378866 Danio rerio
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