Browse our anti-PCSK6 (PCSK6) Antibodies

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anti-Proprotein Convertase Subtilisin/kexin Type 6 Antibodies (PCSK6)
On are 104 Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6) Antibodies from 17 different suppliers available. Additionally we are shipping and many more products for this protein. A total of 112 PCSK6 products are currently listed.
C86343, Pace4, PACE4AIIa, PCSK6, spc4, Xpace4
list all antibodies Gene Name GeneID UniProt
PCSK6 5046 P29122
PCSK6 18553  
PCSK6 25507 Q63415

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anti-Human PCSK6 Antibodies:

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Top referenced anti-PCSK6 Antibodies

  1. Human Polyclonal PCSK6 Primary Antibody for ELISA, WB - ABIN308447 : Jin, Wang, Millar, Quertermous, Rothblat, Glick, Rader: Hepatic proprotein convertases modulate HDL metabolism. in Cell metabolism 2007 (PubMed)

  2. Human Polyclonal PCSK6 Primary Antibody for WB - ABIN658753 : Blanchet, Le Good, Mesnard, Oorschot, Baflast, Minchiotti, Klumperman, Constam: Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation. in The EMBO journal 2008 (PubMed)

  3. Cow (Bovine) Polyclonal PCSK6 Primary Antibody for WB - ABIN2787440 : Yuasa, Suzue, Nagahama, Matsuda, Tsuji: Transcriptional regulation of subtilisin-like proprotein convertase PACE4 by E2F: possible role of E2F-mediated upregulation of PACE4 in tumor progression. in Gene 2007 (PubMed)

  4. Cow (Bovine) Polyclonal PCSK6 Primary Antibody for WB - ABIN2779442 : Koide, Yoshida, Tsuji, Matsuda: The expression of proprotein convertase PACE4 is highly regulated by Hash-2 in placenta: possible role of placenta-specific basic helix-loop-helix transcription factor, human achaete-scute homologue-2. in Journal of biochemistry 2003 (PubMed)

  5. Human Polyclonal PCSK6 Primary Antibody for EIA, WB - ABIN954055 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)

  6. Human Polyclonal PCSK6 Primary Antibody for IHC, IHC (p) - ABIN4343356 : Perisic, Hedin, Razuvaev, Lengquist, Osterholm, Folkersen, Gillgren, Paulsson-Berne, Ponten, Odeberg, Hedin: Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis. in Arteriosclerosis, thrombosis, and vascular biology 2013 (PubMed)

More Antibodies against PCSK6 Interaction Partners

Human Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6) interaction partners

  1. Variants in non-coding sequences of PCSK6 gene is associated with handedness.

  2. These results implicate PCSK6 in mediation of brain developmental pathways that jointly impact upon handedness, autism and aspects of schizotypy

  3. In summary, our study implicated a gene network involving Tbx5 (show TBX5 Antibodies), Osr1 (show OXSR1 Antibodies) and Pcsk6 interaction in second heart field for atrial septation, providing a molecular framework for understanding the role of Tbx5 (show TBX5 Antibodies) in congenital heart disease ontogeny.

  4. PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways

  5. PACE4-knockdown associated growth deficiencies were established on the knockdown HepG2, Huh7, and HT1080 (show CDC123 Antibodies) cells as well as the antiproliferative effects of the multi-Leu peptide supporting the growth capabilities of PACE4 in cancer cells.

  6. identified a PCSK6 mutation that impaired corin (show CORIN Antibodies) activation activity in a hypertensive patient

  7. PCSK6 is upregulated in the synovial tissues of patients with rheumatoid arthritis and has a genetic effect on the risk of rheumatoid arthritis. Inhibition of PCSK6 may play a protective role in the development of rheumatoid arthritis.

  8. PCSK6 regulated by LH inhibits the apoptosis of human granulosa cells via activin A (show INHBA Antibodies) and TGFbeta2.

  9. miR (show MLXIP Antibodies)-124 exhibits antiproliferative and antiaggressive effects on prostate cancer cells through PACE4 pathway.

  10. PCSK6 was detected at increased levels in the fibrous cap of symptomatic carotid plaques, possibly associated with key processes in plaque rupture such as inflammation and extracellular matrix remodeling.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6) interaction partners

  1. PC7 (show PCSK7 Antibodies) and the related proteases Furin (show FURIN Antibodies) and Pace4 regulate E-cadherin (show CDH1 Antibodies) function during blastocyst formation.

  2. Mice overexpressing PACE4 exhibited tumors of increased growth rate.

  3. PACE4 participates in bone formation at least in osteoblast differentiation, and estrogen receptor (show ESR1 Antibodies)-mediated stimuli induce osteoblast differentiation through the upregulation of PACE4 expression

  4. we observed an increased susceptibility to UV in single furin (show FURIN Antibodies) transgenic mice that was not substantially enhanced in the double furin (show FURIN Antibodies)/PACE4 transgenic mice.

  5. A variant in PCSK6 is strongly associated with protection against pain in knee osteoarthritis.

  6. Furin (show FURIN Antibodies) and Pace4 are released by the extraembryonic microenvironment, and that they cleave a membrane-bound reporter substrate in adjacent epiblast cells and activate Nodal to maintain pluripotency

  7. PCSK6 activity plays a role in maintaining normal cellular and tissue homeostasis in the ovary.

  8. PACE4, together with other proprotein convertases, are suitable targets to slow down or block tumor progression.

  9. Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4

  10. Spc4 regulates Nodal signalling during gastrulation

Xenopus laevis Proprotein Convertase Subtilisin/kexin Type 6 (PCSK6) interaction partners

  1. maternal XPACE4 plays an important role in embryonic patterning by regulating the production of a subset of active mature Transforming Growth Factor beta proteins in specific sites

PCSK6 Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression. Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with PCSK6

  • proprotein convertase subtilisin/kexin type 6 (PCSK6) antibody
  • proprotein convertase subtilisin/kexin type 6 (EAMY_2296) antibody
  • proprotein convertase subtilisin/kexin type 6 (pcsk6) antibody
  • proprotein convertase subtilisin/kexin type 6 (Pcsk6) antibody
  • C86343 antibody
  • Pace4 antibody
  • PACE4AIIa antibody
  • PCSK6 antibody
  • spc4 antibody
  • Xpace4 antibody

Protein level used designations for PCSK6

proprotein convertase PACE4 , proprotein convertase subtilisin/kexin type 6 , proprotein convertase subtilisin/kexin type 6-like , paired basic amino acid cleaving enzyme 4 , paired basic amino acid cleaving system 4 , subtilisin-like proprotein convertase 4 , subtilisin/kexin-like protease PACE4 , Subtilisin - like endoprotease , kexin-like protease PC7A , subtilisin-like kinase SPC4

395454 Gallus gallus
743234 Pan troglodytes
8914533 Erwinia amylovora CFBP1430
100057677 Equus caballus
100405129 Callithrix jacchus
100477921 Ailuropoda melanoleuca
100485543 Xenopus (Silurana) tropicalis
5046 Homo sapiens
488703 Canis lupus familiaris
18553 Mus musculus
25507 Rattus norvegicus
446296 Xenopus laevis
100152144 Sus scrofa
524684 Bos taurus
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