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sortilin negatively regulates TGF-beta (show TGFB1 ELISA Kits) signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway
Soluble sortilin exists in cerebrospinal fluid (CSF (show CSF2 ELISA Kits)) in ten-fold molar excess compared to progranulin (show GRN ELISA Kits) and observed a highly significant positive correlation between soluble sortilin and progranulin (show GRN ELISA Kits) levels in CSF (show CSF2 ELISA Kits) but not in plasma. The carriers of the minor allele of SNP rs646776 in SORT1 encoding sortilin displayed significantly increased soluble sortilin and reduced progranulin (show GRN ELISA Kits) specifically in plasma but not in CSF (show CSF2 ELISA Kits).
SORT1 single nucleotide polymorphism and it's association with LDL cholesterol level and risk of coronary heart disease in Pakistani population
Four SNPs within the APOE (show APOE ELISA Kits) cluster (rs7412, rs4420638), ABCC2 (show ABCC2 ELISA Kits) (rs2002042) and CELSR/SORT1/PSRC1 (show PSRC1 ELISA Kits) (rs646776), displayed a major impact on statin efficacy. The wGRS was significantly associated with lower LDL-C at age 75 and 80
In older men, higher serum sortilin levels associated with higher major adverse cerebrovascular/cardiovascular disease risk and severe abdominal aortic calcification.
sortilin is a PIP3 binding protein with binding likely to occur at the C-terminal neurotensin (show NTS ELISA Kits) binding site, and is a competitor of neurotensin (show NTS ELISA Kits)
Focal adhesion kinase-sortilin interactions have an important role in colorectal cancer cells dissociation. (Review)
TDP-43 (show TARDBP ELISA Kits) functions within a network of hnRNP (show HNRNPC ELISA Kits) proteins to inhibit the production of a truncated human SORT1 receptor.
no association was found between the SNPs of rs599839, rs464218 and rs6698843 at the CELSR2 (show CELSR2 ELISA Kits)-PSRC1 (show PSRC1 ELISA Kits)-SORT1 and the risk of coronary artery disease or ischemic stroke
Inverse association between hepatic SORT1 gene expression and hepatic HBsAg expression indicates the possible role of sortilin in HBsAg particle formation.
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles.
Data suggest that sortilin expression in both gastrocnemius and extensor digitorum longus muscle is down-regulated by 17-18h of fasting/food deprivation; pathological levels of high blood glucose, as in streptozotocin-induced diabetes, do not alter sortilin expression in skeletal muscle; sortilin expression is elevated during differentiation of myocyte cell line or in presence of high concentration of glucose.
Shh (show SHH ELISA Kits) and Sort1 can interact at the level of the Golgi and that Sort1 directs Shh (show SHH ELISA Kits) away from the pathways that promote its secretion.
By contrast, treatment with dexamethasone, which also induced insulin (show INS ELISA Kits) resistance, was without effect on sortilin expression and PE production. As a putative bioactive peptide, we have evaluated its autocrine effect by the use of spadin on 3T3-L1 adipocytes by performing glucose uptake and signalling experiments. Any effect was measured on adipocytes indicating that the use of spadin as an antidepressant would have no side
Sortilin 1 (Sort1) knockout (KO) does not affect Western diet-induced obesity nor adipose fatty acid and ceramide concentrations.
sortilin regulates cholestatic liver damage and fibrosis via effects on both aSMase (show SMPD1 ELISA Kits) activity and serum IL-6 (show IL6 ELISA Kits).
This study demonstrated that Mice with Sort1 deficiency display normal cognition but elevated anxiety-like behavior.
TDP-43 (show TARDBP ELISA Kits) functions within a network of hnRNP (show HNRNPH2 ELISA Kits) proteins to inhibit the production of a truncated human SORT1 receptor.
Sortilin is highly expressed in epithelial tissues of the developing lung, nasal cavity, kidney, pancreas and salivary gland.
Sortilin deficiency induces a beneficial metabolic phenotype in liver and adipose tissue upon DIO, mediated in part by reduced aSMase (show SMPD1 ELISA Kits) activity.
This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes\; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p\; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.
, 100 kDa NT receptor
, glycoprotein 95
, neurotensin receptor 3
, glycoprotein 110