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anti-Cynomolgus CD40 Ligand antibody for Functional Studies

Recommended CD40 Ligand Antibody (supplied by: Log in to see )

Antigen
CD40 Ligand (CD40LG) Antibodies
  • CD40-L
  • Cd40l
  • CD40L
  • cd40l
  • CD154
  • gp39
  • hCD40L
  • HIGM1
  • IGM
  • IMD3
  • Ly-62
  • Ly62
  • T-BAM
  • Tnfsf5
  • TNFSF5
  • TRAP
Reactivity
Cynomolgus, Human
450
210
40
15
13
11
7
4
3
3
3
2
2
2
2
Host
Mouse
280
146
103
56
28
26
Clonality
Monoclonal
Conjugate
This CD40 Ligand antibody is un-conjugated
78
60
43
11
11
9
9
8
8
8
7
7
7
7
7
7
7
6
6
6
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS)
373
250
171
59
58
54
52
49
41
22
16
15
11
7
6
6
5
4
3
3
3
2
2
1
1
1
1
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Catalog No. ABIN280698
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00087742624 ABIN1177324 Func FACS Mouse IgG1, kappa Log in to see TRAP1 3
0.00087742624 ABIN282359 Func FACS Mouse IgG1 kappa Log in to see 24-31 1

Top referenced anti-CD40 Ligand antibody for Functional Studies

Similar anti-CD40 Ligand Antibodies

Application / Reactivity Human
Biochemical Assay (BCA) 2 Antibodies
Blocking Antibody (Inhibition) 5 Antibodies
Blocking Reagent (BR) 3 Antibodies
ELISA 157 Antibodies
ELISA (Capture) 4 Antibodies
ELISA (Detection) 1 Antibodies
Enzyme Immunoassay (EIA) 6 Antibodies
Flow Cytometry (FACS) 220 Antibodies
Functional Studies (Func) 30 Antibodies
Immunoassay (IA) 7 Antibodies
Immunocytochemistry (ICC) 23 Antibodies
Immunofluorescence (IF) 18 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 43 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 9 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 30 Antibodies

General

Antigen CD40 Ligand (CD40LG) Antibodies
Reactivity Cynomolgus, Human
(450), (210), (40), (15), (13), (11), (7), (4), (3), (3), (3), (2), (2), (2), (2)
Host Mouse
(280), (146), (103), (56), (28), (26)
Clonality (Clone)
Monoclonal   ( )
Conjugate This CD40 Ligand antibody is un-conjugated
(78), (60), (43), (11), (11), (9), (9), (8), (8), (8), (7), (7), (7), (7), (7), (7), (7), (6), (6), (6), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Functional Studies (Func), Flow Cytometry (FACS)
(373), (250), (171), (59), (58), (54), (52), (49), (41), (22), (16), (15), (11), (7), (6), (6), (5), (4), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-CD40 Ligand Antibody

Target Details CD40 Ligand Application Details Handling References for anti-CD40 Ligand Antibody (ABIN280698) Images
Specificity The 24-31 monoclonal antibody reacts with human CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand (CD40L). CD154 is a member of the TNF superfamily and is expressed transiently by activated T cells. Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry. 24-31 cross-reacts with the cynomolgus monkey CD154.
Characteristics The 24-31 monoclonal antibody reacts with human CD154, a 39 kDa transmembrane glycoprotein also known as gp39 and CD40 ligand (CD40L). CD154 is a member of the TNF superfamily and is expressed transiently by activated T cells. Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry. 24-31 cross-reacts with the cynomolgus monkey CD154.
Synonyms: Synonyms: CD40L
Purification Affinity Purified
Clone 24-31
Isotype IgG1 kappa

Target Details CD40 Ligand

Product Details anti-CD40 Ligand Antibody Application Details Handling References for anti-CD40 Ligand Antibody (ABIN280698) Images back to top
Antigen
Alternative Name CD154 (CD40LG Antibody Abstract)
Background CD154 is a member of the TNF superfamily and is expressed transiently by activated T cells. Through its binding to CD40 on antigen presenting cells including B cells, monocytes/macrophages and dendritic cells, CD154 serves a crucial function in T-APC cognate interaction. CD154 interaction with CD40 transduces signals for T-dependent B-cell activation and induces B cell cycle entry. 24-31 cross-reacts with the Cynomogus monkey CD154.
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways NF-kappaB Signaling

Application Details

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Handling References for anti-CD40 Ligand Antibody (ABIN280698) Images back to top
Application Notes Applications reported: 24-31 has been reported for use in flow cytometric analysis. 24-31 has also been reported to block CD154 binding to CD40 and inhibit T cell- dependent B cell differentiation and antibody response in vitro . (Please use Functional Grade Purified 24-31, cat. 16-1548, in functional assays.)

Applications tested: The 24-31 antibody has been tested by flow cytometric analysis of resting and activated human normal human peripheral blood cells. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
Restrictions For Research Use only

Handling

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Application Details References for anti-CD40 Ligand Antibody (ABIN280698) Images back to top
Concentration 0.5 mg/mL
Buffer aqueous buffer, 0.09 % sodium azide, may contain carrier protein/stabilizer
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Monoclonal antibodies should not be stored at a temperature below -25 °C due to the aggregation effect of the protein.
Storage 4 °C

References for anti-CD40 Ligand Antibody (ABIN280698)

Product Details anti-CD40 Ligand Antibody Target Details CD40 Ligand Application Details Handling Images back to top
Background publications

Brams, Black, Padlan, Hariharan, Leonard, Chambers-Slater, Noelle, Newman: "A humanized anti-human CD154 monoclonal antibody blocks CD154-CD40 mediated human B cell activation." in: International immunopharmacology, Vol. 1, Issue 2, pp. 277-94, 2001

Images

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Supplier Images
 image for anti-CD40 Ligand antibody (CD40LG) (ABIN280698) anti-CD40 Ligand (CD40LG) antibody