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|Antigen||Growth Hormone 1 (GH1) Antibodies|
|Conjugate||This Growth Hormone 1 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|2 references available|
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Product Details anti-Growth Hormone 1 AntibodyTarget Details Growth Hormone 1 Application Details Handling References for anti-Growth Hormone 1 antibody (ABIN121163) Images
|Specificity||The antibody recognizes human Growth Hormone (hGH). Other species not tested.|
|Purification||Protein-G affinity chromatography|
|Immunogen||Recombinant human Growth Hormone protein|
Target Details Growth Hormone 1Product Details anti-Growth Hormone 1 Antibody Application Details Handling References for anti-Growth Hormone 1 antibody (ABIN121163) Images back to top
|Alternative Name||Somatotropin / Growth Hormone / GH1 (GH1 Antibody Abstract)|
|Background||Human growth hormone(hGH, somatotropin), a protein hormone from the anterior lobe of the pituitary gland, comprises a single polypeptide chain of 191 amino acid residues. The 20KDa variant form of human growth hormone (20KDa hGH) presents in extracts from pituitary glands and it differs from the major form of hGH (22KDa, 191 amino acid) by the deletion of amino acid residues 32-46. The growth hormone amino acid sequence varies considerably between species, and non-primate growth hormones have little activity in man. Main functions of hGH and 20KDa hGH are the stimulation of somatic and bone growth, as well as an increase in the size and mass of organs and tissues. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation, an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.Synonyms: Growth hormone 1, HGH, Pituitary growth hormone|
|Pathways||NF-kappaB Signaling, JAK-STAT Signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process|
Application DetailsProduct Details anti-Growth Hormone 1 Antibody Target Details Growth Hormone 1 Handling References for anti-Growth Hormone 1 antibody (ABIN121163) Images back to top
ELISA. Western blot (1:500 - 1:1,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-Growth Hormone 1 Antibody Target Details Growth Hormone 1 Application Details References for anti-Growth Hormone 1 antibody (ABIN121163) Images back to top
|Buffer||PBS, pH 7.4, containing 0.09 % sodium azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.
|Expiry Date||12 months|
References for anti-Growth Hormone 1 antibody (ABIN121163)Product Details anti-Growth Hormone 1 Antibody Target Details Growth Hormone 1 Application Details Handling Images back to top
Chang, Nunberg, Kaufman, Erlich, Schimke, Cohen: "Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase." in: Nature, Vol. 275, Issue 5681, pp. 617-24, 1978
Ullrich, Shine, Chirgwin, Pictet, Tischer, Rutter, Goodman: "Rat insulin genes: construction of plasmids containing the coding sequences." in: Science (New York, N.Y.), Vol. 196, Issue 4296, pp. 1313-9, 1977