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|Application / Reactivity||Mouse (Murine)|
|Dot Blot (DB)||21 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||3 Antibodies|
|Immunofluorescence (IF)||15 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||47 Antibodies|
|Immunohistochemistry (IHC)||39 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||21 Antibodies|
|Immunoprecipitation (IP)||3 Antibodies|
|Western Blotting (WB)||68 Antibodies|
|Antigen||Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This IKBKB antibody is un-conjugated Alternatives|
Dot Blot (DB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-IKBKB AntibodyTarget Details IKBKB Application Details Handling References for anti-IKBKB Antibody (ABIN1881452) Images
|Purification||This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Immunogen||This mouse IKKB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S701 of mouse IKKB.|
Target Details IKBKBProduct Details anti-IKBKB Antibody Application Details Handling References for anti-IKBKB Antibody (ABIN1881452) Images back to top
|Alternative Name||IKKB (IKBKB Antibody Abstract)|
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).
Synonyms: Ikbkb, Ikkb, Inhibitor of nuclear factor kappa-B kinase subunit beta, I-kappa-B kinase 2, Nuclear factor NF-kappa-B inhibitor kinase beta
|Pathways||NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-IKBKB Antibody Target Details IKBKB Handling References for anti-IKBKB Antibody (ABIN1881452) Images back to top
|Application Notes||DB: 1:500|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IKBKB Antibody Target Details IKBKB Application Details References for anti-IKBKB Antibody (ABIN1881452) Images back to top
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.|
|Precaution of Use||WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.|
References for anti-IKBKB Antibody (ABIN1881452)Product Details anti-IKBKB Antibody Target Details IKBKB Application Details Handling Images back to top
|Product cited in:||
Busuttil, Droin, McCormick et al.: "NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 42, pp. 18061-6, 2010 (PubMed).
Tsuchiya, Asano, Nakayama et al.: "Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation." in: Molecular cell, Vol. 39, Issue 4, pp. 570-82, 2010 (PubMed).
Kenneth, Mudie, Rocha: "IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function." in: The EMBO journal, Vol. 29, Issue 17, pp. 2966-78, 2010 (PubMed).
Farlik, Reutterer, Schindler et al.: "Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression." in: Immunity, Vol. 33, Issue 1, pp. 25-34, 2010 (PubMed).
ImagesProduct Details anti-IKBKB Antibody Target Details IKBKB Application Details Handling References for anti-IKBKB Antibody (ABIN1881452) back to top