IKBKB antibody (N-Term)
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- Target See all IKBKB Antibodies
- IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
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Binding Specificity
- N-Term
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Reactivity
- Human, Mouse, Rat, Cow, Horse, Dog, Rabbit, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This IKBKB antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- CITGFRPFLP NWQPVQWHSK VRQKSEVDIV VSEDLNGTVK FSSSLPYPNN
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against IKBKB. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human IKBKB
- Top Product
- Discover our top product IKBKB Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 756 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- IKBKB (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase beta (IKBKB))
- Alternative Name
- IKBKB (IKBKB Products)
- Synonyms
- ikk-beta antibody, ikk2 antibody, ikkb antibody, ikkbeta antibody, IKBKB antibody, IKKB antibody, CG4201 antibody, DIK antibody, DLAK antibody, DmIKK antibody, DmIKKBeta antibody, DmIKKb antibody, DmIKKbeta antibody, DmIkkbeta antibody, Dmel\\CG4201 antibody, Dmikkb antibody, Dmikkbeta antibody, IK antibody, IKK antibody, IKK-beta antibody, IKKb antibody, IKKbeta antibody, IRD-5 antibody, IRD5 antibody, Ik antibody, Ikkb antibody, Ikkbeta antibody, Ird-5 antibody, Ird5 antibody, LRK antibody, Lak antibody, anon-89Bd antibody, dIKK antibody, dIKK-beta antibody, dIKKbeta antibody, dLak antibody, dmIKKbeta antibody, ikk antibody, ird antibody, ird5/DmIkk[beta] antibody, IKK2 antibody, NFKBIKB antibody, AIM-1 antibody, AI132552 antibody, IKK-2 antibody, IKK[b] antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta L homeolog antibody, inhibitor of nuclear factor kappa B kinase subunit beta antibody, I-kappaB kinase beta antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta antibody, inhibitor of kappaB kinase beta antibody, ikbkb.L antibody, IKBKB antibody, ikbkb antibody, IKKbeta antibody, Ikbkb antibody
- Background
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NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA (MIM 164014), or RELB (MIM 604758) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008, or NFKBIB, MIM 604495), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T, R is an A or G purine, and Y is a C or T pyrimidine).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-203 AL708460.1 9-211 204-3077 AF080158.1 170-3043 3078-3916 AK023193.1 1980-2818
Alias Symbols: FLJ40509, IKK-beta, IKK2, IKKB, MGC131801, NFKBIKB
Protein Interaction Partner: BCL10, IKBKG, UBC, Snap23, RELA, NFKBIA, MTOR, RPTOR, ROCK1, IKBKB, CDC37, KEAP1, MAP3K7, FLNC, NGFR, EGLN3, SASH1, COPS5, COPS3, PPP1CA, TPX2, TNFRSF1A, AURKA, PRKCQ, MAP3K1, TFAP2C, NLRC5, PYCARD, TAB2, IKBKE, MAP3K14, CHUK, HSPB1, PRKCE, NAA20, TRAF3IP
Protein Size: 756 - Molecular Weight
- 86 kDa
- Gene ID
- 3551
- NCBI Accession
- NM_001556, NP_001547
- UniProt
- O14920
- Pathways
- NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Production of Molecular Mediator of Immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
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