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|Antigen||Lymphotoxin beta Receptor (TNFR Superfamily, Member 3) (LTBR) Antibodies|
|Epitope||AA 1-218 Alternatives|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This LTBR antibody is un-conjugated Alternatives|
|Supplier||Log in to see|
Product Details anti-LTBR AntibodyTarget Details LTBR Application Details Handling Images
|Characteristics||Produced in rabbits immunized with purified, recombinant Rat LTBR (rR LTBR, ABIN2009258 NP_001008316.1, Met1-Ala218,. Total IgG was purified by Protein A affinity chromatography.|
|Purification||purified by Protein A affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Rat LTBR protein (ABIN2009258)|
Target Details LTBRProduct Details anti-LTBR Antibody Application Details Handling Images back to top
|Alternative Name||LTBR (LTBR Antibody Abstract)|
|Background||LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) contains 4 TNFR-Cys repeats and belongs to the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. It is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. LTBR has been shown to interact with diablo homolog and TRAF3. It can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. LTBR is also essential for development and organization of the secondary lymphoid organs and chemokine release. It specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells.|
|Research Area||Chromatin and Nuclear Signaling, Apoptosis/Necrosis|
Application DetailsProduct Details anti-LTBR Antibody Target Details LTBR Handling Images back to top
ELISA: 0.5-1 μg/mL
This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Rat LTBR. The detection limit for Rat LTBR is approximately ≤ 0.039 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-LTBR Antibody Target Details LTBR Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|