Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4 (show TLR4 ELISA Kits)-mediated JNK (show MAPK8 ELISA Kits) and p38 MAPK (show MAPK14 ELISA Kits) Activation
The data emphasize the central role of TAK1 in controlling signaling cascades and functional responses in primary neutrophils, making it a promising target for therapeutic intervention in view of the role of neutrophils in chronic inflammatory conditions.
MiR (show MLXIP ELISA Kits)-377 is an important negative regulator of E2F (show E2F1 ELISA Kits) and MAP3K7/NF-kB signaling pathway in melanoma cells.
the TAK1 signaling pathway may represent a suitable target to design new, antifibrotic therapies
Findings indicate that SHIP2 (show INPPL1 ELISA Kits) is a regulator of lymphatic function in humans and that inherited mutations in the INPPL1 (show INPPL1 ELISA Kits) gene may act in concert with HGF (show HGF ELISA Kits), and likely MAP3K7, mutations to exacerbate lymphatic phenotypes.
Data indicate that inhibition of TGF-beta (show TGFB1 ELISA Kits)-activated protein kinase (show CDK7 ELISA Kits) 1 (TAK1) reduces chemokine (C-C motif) receptor 7 (CCR7 (show CCR7 ELISA Kits)) expression.
identify coordinate loss of MAP3K7 and CHD1 (show CHD1 ELISA Kits) as a unique driver of aggressive prostate cancer development
Data indicate 4-substituted 1H-pyrrolo[2,3-b]pyridines as potent inhibitors against TGFbeta (show TGFB1 ELISA Kits)-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2 (show MAP4K2 ELISA Kits)).
Ubc13 (show UBE2N ELISA Kits) was dispensable for transforming growth factor beta (TGFbeta (show TGFB1 ELISA Kits))-induced SMAD (show SMAD1 ELISA Kits) activation but was required for activation of non-SMAD (show SMAD1 ELISA Kits) signaling via TGFbeta (show TGFB1 ELISA Kits)-activating kinase 1 (TAK1) and p38 (show CRK ELISA Kits)
Data show that the ECSIT (evolutionarily conserved signaling intermediate in Toll (show TLR4 ELISA Kits) pathways) complex, including MEKK7 (TAK1) and TNF receptor-associated factor 6 (TRAF6 (show TRAF6 ELISA Kits)), plays a role in Toll-like receptor 4 (show TLR4 ELISA Kits) -mediated signals to activate NF-kappa B (show NFKB1 ELISA Kits).
TAK1 (show NR2C2 ELISA Kits) and IKK2 (show IKBKB ELISA Kits) are novel mediators of SCF (show KITLG ELISA Kits)-induced signaling and potential targets for c-Kit (show KIT ELISA Kits)-driven diseases.
TAKI-induced cytotoxicity is cell context specific, and apoptosis observed in macrophages is dependent on the constitutive autocrine action of TNF-alpha (show TNF ELISA Kits) for RIP1 (show RALBP1 ELISA Kits) activation and ROS (show ROS1 ELISA Kits) production.
These results suggest a crucial role for TAK1 (show NR2C2 ELISA Kits) for maintaining the survival of committed regulatory T cells under physiological conditions.
A possible mechanism by which tomoregulin-1 regulates the development of cardiac hypertrophy in TAC (show IL2RA ELISA Kits)-induced cardiac hypertrophy is through inhibiting TGFbeta (show TGFB1 ELISA Kits) non-canonical (TAK1 (show NR2C2 ELISA Kits)-JNK (show MAPK8 ELISA Kits)) pathways in the myocardium.
findings demonstrate that GC resistance for TAK1 (show NR2C2 ELISA Kits) activation associated with TLR4 (show TLR4 ELISA Kits) engagement may be an important contributor to GC resistance in inflammatory disorders.
TAK1 (show NR2C2 ELISA Kits) regulates osteoclastogenesis by integrating activation of NF-kappaB (show NFKB1 ELISA Kits) and derepression of NOTCH (show NOTCH1 ELISA Kits)/RBPJ (show RBPJ ELISA Kits) in myeloid cells through inhibition of NUMBL (show NUMBL ELISA Kits).
Epithelium-specific Tak1 (show NR2C2 ELISA Kits):Smad4 (show SMAD4 ELISA Kits)- and Trim33 (show TRIM33 ELISA Kits):Smad4 (show SMAD4 ELISA Kits)-double mutants display reduced expression of Mmp13 (show MMP13 ELISA Kits) in palatal medial edge epithelial cells.
TAK1 (show NR2C2 ELISA Kits) regulates hepatic lipid metabolism and tumorigenesis via the AMPK (show PRKAA1 ELISA Kits)/mTORC1 axis, affecting both autophagy and PPARalpha (show PPARA ELISA Kits) activity.
Nef markedly activated TAK1 (show NR2C2 ELISA Kits) in M-CSF (show CSF1R ELISA Kits)-derived M2-MPhi but not in GM-CSF (show CSF2 ELISA Kits)-derived M1-MPhi.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1