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This study suggests that aberrant activity of TAK1 impairs autophagy and subsequently leads to alterations in the vitality of retinal pigment epithelial cells.
TAK1 may be an important factor involved in the pathogenesis of thyroid cancer, and targeted down-regulation of TAK1 may improve the prognosis of patients with thyroid cancer.
Loss of MAP3K7 are associated with esophageal squamous cell carcinoma.
This paper highlights that targeting the BMP and TGFbeta (show TGFB1 ELISA Kits) type I and type II receptors causes a downregulation of XIAP (show XIAP ELISA Kits), TAK1, and Id1 (show ID1 ELISA Kits) leading to cell death of lung cancer cells.
Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4 (show TLR4 ELISA Kits)-mediated JNK (show MAPK8 ELISA Kits) and p38 MAPK (show MAPK14 ELISA Kits) Activation
The data emphasize the central role of TAK1 in controlling signaling cascades and functional responses in primary neutrophils, making it a promising target for therapeutic intervention in view of the role of neutrophils in chronic inflammatory conditions.
MiR (show MLXIP ELISA Kits)-377 is an important negative regulator of E2F (show E2F1 ELISA Kits) and MAP3K7/NF-kB signaling pathway in melanoma cells.
the TAK1 signaling pathway may represent a suitable target to design new, antifibrotic therapies
Findings indicate that SHIP2 (show INPPL1 ELISA Kits) is a regulator of lymphatic function in humans and that inherited mutations in the INPPL1 (show INPPL1 ELISA Kits) gene may act in concert with HGF (show HGF ELISA Kits), and likely MAP3K7, mutations to exacerbate lymphatic phenotypes.
Data indicate that inhibition of TGF-beta (show TGFB1 ELISA Kits)-activated protein kinase (show CDK7 ELISA Kits) 1 (TAK1) reduces chemokine (C-C motif) receptor 7 (CCR7 (show CCR7 ELISA Kits)) expression.
Data show that TGFbeta (show TGFB1 ELISA Kits)-activated kinase-1 (TAK1 (show NR2C2 ELISA Kits)) activated nuclear factor of activated T-cells (NFAT (show NFATC1 ELISA Kits))/NF-kappa B (NFkappaB (show NFKB1 ELISA Kits)), downregulated BCL2-adenovirus E1B interacting protein 3 (Bnip3 (show BNIP3 ELISA Kits)), and inhibited cardiac cell death.
Crucial functions of inflammatory TAK1 (show NR2C2 ELISA Kits)-NEMO (show IKBKG ELISA Kits) signaling in protecting the brain endothelium and maintaining normal brain function.
Roles of TAK1 (show NR2C2 ELISA Kits) in vascular oxidative stress and its contribution to neointima formation after vascular injury.
Inactivation of TAK1 (show NR2C2 ELISA Kits) in satellite cells inhibits muscle regeneration in adult mice.
our current study highlighted the emerging role of TAK1 (show NR2C2 ELISA Kits) in configuring the gut (show GUSB ELISA Kits)-specialized T cell subset, which regulates mucosal homeostasis under lymphopenic conditions.
the ADAP (show APP ELISA Kits) CARMA1 (show CARD11 ELISA Kits) binding site is required for IKK gamma (show IKBKG ELISA Kits) ubiquitination; both TAK1 (show NR2C2 ELISA Kits) and CARMA1 (show CARD11 ELISA Kits) binding sites are required for IkappaB alpha (show NFKBIA ELISA Kits) phosphorylation and degradation and NF-kappaB (show NFKB1 ELISA Kits) nuclear translocation
Results provide evidence that TAK1 (show NR2C2 ELISA Kits) is required for the activation of NF-kappaB (show NFKB1 ELISA Kits) in thymocytes and suggest that TAK1 (show NR2C2 ELISA Kits) plays a central role in both innate and adaptive immunity.
TAK1 (show NR2C2 ELISA Kits) is essential for connective tissue deposition in the dermis.
Tak1 functions to regulate tongue development by controlling Fgf10 expression and could represent a candidate gene for mutation in human PRS clefting.
In vivo knockdown of TAK1 (show NR2C2 ELISA Kits) accelerates bone marrow proliferation/differentiation and induces systemic inflammation.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1