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TAK1 regulates Nrf2 (show GABPA ELISA Kits) through modulation of Keap-p62/SQSTM1 (show SQSTM1 ELISA Kits) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Overexpression of TAK1 was strongly associated with positive lymph node metastasis in pancreatic ductal adenocarcinoma.
dysregulation of the TAK1 complex produces a close phenocopy of Frontometaphyseal Dysplasia caused by FLNA (show FLNA ELISA Kits) mutations; furthermore, the pathogenesis of some of the filaminopathies caused by FLNA (show FLNA ELISA Kits) mutations might be mediated by misregulation of signaling coordinated through the TAK1 signaling complex
although TAK1 is located at the crossroad of inflammation, immunity, and cancer, this study reports MAP3K7 mutations in a developmental disorder affecting mainly cartilage, bone, and heart
This study suggests that aberrant activity of TAK1 impairs autophagy and subsequently leads to alterations in the vitality of retinal pigment epithelial cells.
TAK1 may be an important factor involved in the pathogenesis of thyroid cancer, and targeted down-regulation of TAK1 may improve the prognosis of patients with thyroid cancer.
Loss of MAP3K7 are associated with esophageal squamous cell carcinoma.
This paper highlights that targeting the BMP and TGFbeta (show TGFB1 ELISA Kits) type I and type II receptors causes a downregulation of XIAP (show XIAP ELISA Kits), TAK1, and Id1 (show ID1 ELISA Kits) leading to cell death of lung cancer cells.
Polyubiquitination of Transforming Growth Factor beta-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4 (show TLR4 ELISA Kits)-mediated JNK (show MAPK8 ELISA Kits) and p38 MAPK (show MAPK14 ELISA Kits) Activation
The data emphasize the central role of TAK1 in controlling signaling cascades and functional responses in primary neutrophils, making it a promising target for therapeutic intervention in view of the role of neutrophils in chronic inflammatory conditions.
Tnfr1 (show TNFRSF1A ELISA Kits) deletion partially restored thymic and lung macrophages.
TAK1 (show NR2C2 ELISA Kits) is required for PPARgamma (show PPARG ELISA Kits) transactivation and promotes PPARgamma (show PPARG ELISA Kits) transcriptional activity synergistically with TAK1 binding protein 1 (TAB1 (show TAB1 ELISA Kits)).
inhibition of TAK1 (show NR2C2 ELISA Kits) triggered two caspase 8 (show CASP8 ELISA Kits) activation pathways through the induction of RIP1 (show RALBP1 ELISA Kits)-FADD (show FADD ELISA Kits)-caspase 8 (show CASP8 ELISA Kits) complex as well as FLIP cleavage/degradation.
Transforming growth factor-beta activated kinase 1 (TAK1) regulation of sterol-regulatory element-binding proteins (SREBPs) critically contributes to the maintenance of liver homeostasis to prevent steatosis, which is a potentially important mechanism to prevent hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) development.
TAK1 (show NR2C2 ELISA Kits) regulates Nrf2 (show NFE2L2 ELISA Kits) through modulation of Keap-p62/SQSTM1 (show SQSTM1 ELISA Kits) interaction. This regulation is important for homeostatic antioxidant protection in the intestinal epithelium.
Mekk1 (show MAP2K1 ELISA Kits) (encoded by Map3k1 (show MAP3K1 ELISA Kits)) signaling activates Mapks to regulate Cdkn1b (show CDKN1B ELISA Kits) (encoding p27(Kip1 (show CDKN1B ELISA Kits))) expression and p27(Kip1 (show CDKN1B ELISA Kits))-dependent proliferative expansion in response to antigen.
TRADD (show TRADD ELISA Kits) knockout blunts pressure overload-induced cardiac hypertrophy through mediating TAK1 (show NR2C2 ELISA Kits)/p38 MAPK (show MAPK14 ELISA Kits) but not AKT (show AKT1 ELISA Kits) phosphorylation
this study demonstrates a pivotal role of TAK1 (show NR2C2 ELISA Kits) in dendritic cells in controlling trichloroethylene-induced contact hypersensitivity response and suggests that targeting TAK1 (show NR2C2 ELISA Kits) function in DCs may be a viable approach to preventing and treating TCE-related occupational health hazards
The E3 ligase TRIM8 (show TRIM8 ELISA Kits) is a potent regulator that exacerbates steatohepatitis and metabolic disorders dependent on its binding and ubiquitinating capacity on transforming growth factor-beta-activated kinase 1.
Angiotensin-II up-regulates the Ampkalpha1 (show PRKAA1 ELISA Kits) isoform in renal tissue. Ampkalpha1 (show PRKAA1 ELISA Kits) participates in renal Tak1 (show NR2C2 ELISA Kits) activation and Tak1 (show NR2C2 ELISA Kits)-dependent signaling induced by angiotensin-II.
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
mitogen-activated protein kinase kinase kinase 7
, TGF-beta-activated kinase TAK1
, TGF-beta activated kinase 1
, TGF-beta-activated kinase 1
, transforming growth factor-beta-activated kinase 1
, mitogen activated protein kinase kinase kinase 7
, transforming growth factor beta-activated kinase 1