Browse our anti-NFKBIA (NFKBIA) Antibodies

Full name:
anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha Antibodies (NFKBIA)
On www.antibodies-online.com are 498 Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) Antibodies from 36 different suppliers available. Additionally we are shipping NFKBIA Kits (34) and NFKBIA Proteins (10) and many more products for this protein. A total of 561 NFKBIA products are currently listed.
Synonyms:
AI462015, ECI-6/IKBA, IKBA, MAD-3, NFKBI, RL/IF-1
list all antibodies Gene Name GeneID UniProt
NFKBIA 18035 Q9Z1E3
NFKBIA 4792 P25963
NFKBIA 25493 Q63746

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Top referenced anti-NFKBIA Antibodies

  1. Human Monoclonal NFKBIA Primary Antibody for CyTOF, FACS - ABIN252471 : Saccani, Pantano, Natoli: p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. in Nature immunology 2001 (PubMed)
    Show all 32 references for 252471

  2. Human Polyclonal NFKBIA Primary Antibody for EIA, WB - ABIN357736 : Miskolci, Castro-Alcaraz, Nguyen, Vancura, Davidson, Vancurova: Okadaic acid induces sustained activation of NFkappaB and degradation of the nuclear IkappaBalpha in human neutrophils. in Archives of biochemistry and biophysics 2003 (PubMed)
    Show all 5 references for 357736

  3. Human Polyclonal NFKBIA Primary Antibody for DB - ABIN650851 : Wu, Walenkamp, Lankester, Bidlingmaier, Wit, De Luca: Growth hormone and insulin-like growth factor I insensitivity of fibroblasts isolated from a patient with an I{kappa}B{alpha} mutation. in The Journal of clinical endocrinology and metabolism 2010 (PubMed)
    Show all 2 references for 650851

  4. Human Polyclonal NFKBIA Primary Antibody for FACS, IF - ABIN652417 : Tojima, Fujimoto, Delhase, Chen, Hatakeyama, Nakayama, Kaneko, Nimura, Motoyama, Ikeda, Karin, Nakanishi: NAK is an IkappaB kinase-activating kinase. in Nature 2000 (PubMed)
    Show all 2 references for 652417

  5. Human Polyclonal NFKBIA Primary Antibody for WB - ABIN389074 : Place, Haspeslagh, Giardina: Induced stabilization of IkappaBalpha can facilitate its re-synthesis and prevent sequential degradation. in Journal of cellular physiology 2003 (PubMed)

  6. Human Polyclonal NFKBIA Primary Antibody for IF, IHC - ABIN1531880 : Haskill, Beg, Tompkins, Morris, Yurochko, Sampson-Johannes, Mondal, Ralph, Baldwin: Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity. in Cell 1991 (PubMed)

  7. Cow (Bovine) Polyclonal NFKBIA Primary Antibody for WB - ABIN2792229 : Truhlar, Mathes, Cervantes, Ghosh, Komives: Pre-folding IkappaBalpha alters control of NF-kappaB signaling. in Journal of molecular biology 2008 (PubMed)

  8. Human Polyclonal NFKBIA Primary Antibody for IHC, WB - ABIN2792665 : Janssen, van Wengen, Hoeve, ten Dam, van der Burg, van Dongen, van de Vosse, van Tol, Bredius, Ottenhoff, Weemaes, van Dissel, Lankester: The same IkappaBalpha mutation in two related individuals leads to completely different clinical syndromes. in The Journal of experimental medicine 2004 (PubMed)

More Antibodies against NFKBIA Interaction Partners

Mouse (Murine) Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) interaction partners

  1. Mechanistic analysis suggest that USP12 may be required for the activation of NFkappaB pathway as knockdown of USP12 reduced the inhibitory phosphorylation of IkappaBalpha, a well characterized inhibitor of NFkappaB nuclear translocation.

  2. SM22alpha (show TAGLN Antibodies) is a phosphorylation-regulated (show PHAX Antibodies) suppressor of IKK (show CHUK Antibodies)-IkappaBalpha-NF-kappaB (show NFKB1 Antibodies) signaling cascades.

  3. We found potential links between the alterations in expression of Tsc22d3 (show TSC22D3 Antibodies), Nfkbia and Pdyn (show PDYN Antibodies), and different aspects of susceptibility to stress.

  4. Specific and constitutive deletion of the inhibitor of NF-kappaB (show NFKB1 Antibodies) (IkappaBalpha) in eosinophils in vivo reduced apoptosis during helminth infection

  5. GRK6 (show GRK6 Antibodies) directly phosphorylates Nfkbia at Ser32/Ser36. Knockdown of GRK6 (show GRK6 Antibodies) suppresses TNF-alpha (show TNF Antibodies)-induced NF-kappaappaB signaling.

  6. Results demonstrate novel roles of TNFRII (show TNFRSF1B Antibodies) in the regulation of Abeta (show APP Antibodies) production, suggesting a potential therapeutic strategy for Alzheimer's disease by up-regulating TNFRII (show TNFRSF1B Antibodies) levels and elevating phosphorylated IkappaBalpha by SUMOylation.

  7. Defective lymphoid organogenesis underlies the immune deficiency caused by a heterozygous S32I mutation in IkappaBalpha.

  8. Dengue virus protease interacts with both NF-kappaB inhibitor alpha (IkappaBalpha) and NF-kappaB (show NFKB1 Antibodies) inhibitor beta (IkappaBbeta (show NFKBIB Antibodies)), cleaving them in a mouse hemorrhage model.

  9. The results indicate that following heat shock treatment, HuR (show ELAVL1 Antibodies) translocates from the nucleus to the cytoplasm, forming stress granules and regulating the translation of IkBalpha mRNA without affecting the half-life.

  10. Data show that inhibition of nuclear factor-kappaB (NF-kappaB (show NFKB1 Antibodies)) in IKBM protects the mice from monocrotaline (MCT (show MCAT Antibodies))-induced pulmonary arterial hypertension and right ventricular hypertrophy.

Human Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) interaction partners

  1. The results showed that NFKB1 (show NFKB1 Antibodies) and NFKBIA single-nucleotide polymorphisms and gastric cancer are related and that the combined effects of polymorphisms in two genes and the NFKBIA gene monomer increased the risk of gastric cancer, and it was found that in different types of gastric cancer (the cardia and non-cardia cancer), susceptible polymorphism sites and combined effects are different.

  2. Double phosphorylation-induced structural changes in the signal-receiving domain of IkappaBalpha in complex with NF-kappaB (show NFKB1 Antibodies) have been described.

  3. Here, the authors report amide hydrogen/deuterium exchange data that reveal long-range allosteric changes in the NFkappaB (show NFKB1 Antibodies) (RelA (show NFkBP65 Antibodies)-p50 (show CD40 Antibodies)) heterodimer induced by DNA or IkappaBalpha binding.

  4. Sam68 (show KHDRBS1 Antibodies) is essential for DNA damage-induced NF-kappaB (show NFKB1 Antibodies) activation and colon tumorigenesis.

  5. Specifically, BCA2 (show RNF115 Antibodies) serves as an E3 SUMO ligase in the SUMOylation of IkappaBalpha, which in turn enhances the sequestration of NF-kappaB (show NFKB1 Antibodies) components in the cytoplasm. Since HIV-1 utilizes NF-kappaB (show NFKB1 Antibodies) to promote proviral transcription, the BCA2 (show RNF115 Antibodies)-mediated inhibition of NF-kappaB (show NFKB1 Antibodies) significantly decreases the transcriptional activity of HIV-1.

  6. This study found that NFKBIA mRNAs was significantly expressed in normal tissues compared with glioma specimens.

  7. Findings indicate the prognostic value of NFKB inhibitor alpha (NFKBIA) in lower-grade gliomas (LGGs).

  8. W346 effectively inhibited tumor necrosis factor (TNF-a (show TNF Antibodies))-induced NF-kappaB (show NFKB1 Antibodies) activation by suppressing IKK (show CHUK Antibodies) phosphorylation, inhibiting IkB (show NFKBIB Antibodies)-a degradation, and restraining the accumulation of NF-kappaB (show NFKB1 Antibodies) subunit p65 (show GORASP1 Antibodies) nuclear translocation. W346 also affected NF-kappaB (show NFKB1 Antibodies)-regulated downstream products involved in cycle arrest and apoptosis.

  9. treating cells with SZC014 resulted in a decrease in phosphorylation of IkBa and NF-kappaB (show NFKB1 Antibodies)/p65 (show GORASP1 Antibodies) and NF-kappaB (show NFKB1 Antibodies)/p65 (show GORASP1 Antibodies) nuclear translocation. The cytotoxic activities of seven OA derivatives were generally stronger than that of OA, among which, SZC014 possessed the most potent anticancer activity in SGC7901 cells and would be a promising chemotherapic agent for the treatment of gastric cancer

  10. Network analysis identified NFKBIA as pathogenic gene in childhood asthma.

Cow (Bovine) Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) interaction partners

  1. IkappaB-alpha protein was stabilized by COMMD1 (show COMMD1 Antibodies), which attenuated NF-kappaB (show NFKB1 Antibodies) signaling during Toll (show TLR4 Antibodies)-like receptor ligand and tumor necrosis factor alpha (show TNF Antibodies) treatment and enhanced HIV-1 latency in latently HIV-1-infected cells.

  2. NFKBIA has a role as a marker of NF-kappaB (show NFKB1 Antibodies)/p65 (show SYT1 Antibodies) activation in the early embryo.

  3. NF-kappaB (show NFKB1 Antibodies) has a role in increasing PDGF-B (show PDGFB Antibodies) transcription

  4. AIP1 (show PDCD6IP Antibodies) is a novel transducer in TNF (show TNF Antibodies)-induced TRAF2 (show TRAF2 Antibodies)-dependent activation of ASK1 (show MAP3K5 Antibodies) that mediates a balance between JNK (show MAPK8 Antibodies) versus NF-kappaB (show NFKB1 Antibodies) signaling

  5. GRK5 overexpression causes nuclear accumulation of IkappaB alpha, leading to the inhibition of NFkappaB transcriptional activity.

NFKBIA Antigen Profile

Antigen Summary

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

Alternative names and synonyms associated with NFKBIA

  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (NFKBIA) antibody
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (LOC100220015) antibody
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (LOC100357341) antibody
  • nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha (Nfkbia) antibody
  • nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (Nfkbia) antibody
  • AI462015 antibody
  • ECI-6/IKBA antibody
  • IKBA antibody
  • MAD-3 antibody
  • NFKBI antibody
  • RL/IF-1 antibody

Protein level used designations for NFKBIA

NF-kappa-B inhibitor alpha , nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha , I(Kappa)B(alpha) , I-kappa-B-alpha , I-kappaBalpha , ikB-alpha , ikappaBalpha , nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha , nuclear factor of kappa light polyp gene enhancer in B-cell 1 , IkappaBalpha , major histocompatibility complex enhancer-binding protein MAD3 , nuclear factor of kappa light chain gene enhancer in B-cells , ECI-6 , I kappa B-alpha , IKB-alpha , NF-kappaB inhibitor alpha , REL-associated protein pp40 , Rel-associated pp40 , IkappaB alpha , Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha , Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha

GENE ID SPECIES
780520 Ovis aries
100220015 Taeniopygia guttata
100357341 Oryctolagus cuniculus
18035 Mus musculus
4792 Homo sapiens
406188 Sus scrofa
396093 Gallus gallus
480291 Canis lupus familiaris
282291 Bos taurus
25493 Rattus norvegicus
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