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The data imply that regulation of these c-Rel (show NFkBP65 Proteins)-dependent lymphoid responses is a non-redundant function of IkappaBepsilon.
temporal control of NF-kappaB (show NFKB1 Proteins) activation by the coordinated degradation and synthesis of IkappaB proteins
IkappaBepsilon deficiency in mice leads to neonatal death, elevated kappaB binding activity, overexpression of NF-kappaB (show NFKB1 Proteins) target genes, and disruption of lymphocyte production.
Neither IkappaBalpha (show NFKBIA Proteins) nor IkappaBepsilon deficiency had major effects on natural killer cell generation while their combined absence led to NF-kappaB (show NFKB1 Proteins) hyperactivation.
An important role is proposed for I kappa B epsilon in the differential regulation of nuclear NF-kappa B (show NFKB1 Proteins) activity in stimulated B cells.
In vivo degradation rate constants were measured for NF-kappaB (show NFKB1 Proteins)-bound & -unbound IkappaB. Models suggest differential degradation rates of free & bound IkappaB may be a new cross-regulation mechanism imparting functional robustness to the signaling module.
results show that Gal-1 (show LGALS1 Proteins) acts by inhibiting the stimulation of the LPS (show IRF6 Proteins)-induced IkappaBzeta (show NFKBIZ Proteins) expression, an NF-kappaB (show NFKB1 Proteins) regulator involved in IL-6 (show IL6 Proteins) gene transcription.
Newly identified alterations included recurrent promoter mutations of NFKBIE, encoding NF-kappaB (show NFKB1 Proteins) inhibitor varepsilon (IkappaBvarepsilon), in 14.5% of samples of desmoplastic melanoma
IkappaBepsilon has a role in NF-kappaB (show NFKB1 Proteins) regulation in aggressive chronic lymphocytic leukemia
Vitamin C forestalls cigarette smoke induced NF-kappaB (show NFKB1 Proteins) activation in alveolar epithelial cells.
we identified two gene loci associated with rheumatoid arthritis susceptibility- NFKBIE and RTKN2 (show RTKN2 Proteins)
Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon
An NFKBIE SNP associated with susceptibility to pneumococcal disease but not pneumococcal empyema.
Expression levels of GGT1 (show GGT1 Proteins) and possibly NFKBIE might be useful as biomarkers of genetic susceptibility to arsenite.
Genomic mutation of the NFKBIE gene in primary Hodgkin/ Reed Sternberg cells
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus.
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
, NF-kappa-B inhibitor epsilon
, solute carrier family 35, member B2