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AP-2alpha (show TFAP2A Proteins) depletion enhanced apoptosis, demonstrating that disrupting the HIV-1 Nef:AP-2alpha interaction limits Nef-mediated apoptosis.
These results lead to a model for the docking of the full AP-2 (show GTF3A Proteins) tetramer to membranes as bound to Nef, such that the cytosolic tail of CD4 (show CD4 Proteins) is situated to interact with its binding site on Nef.
AP2alpha negatively regulates HIV-1 replication in the process of nuclear translocation of viral DNA in the cytoplasm or the perinuclear region.
nef usurps AP-2 complexes to dysregulate Ii (invariant chain (Ii)/major histocompatibility complex class II) trafficking and potentially interfere with antigen presentation in the context of MHC-II
SP-A transiently enhances the basal protein expression of CHC and alpha-adaptin.
AP2 (show TFAP2A Proteins) protein expression was regulated in a vitamin A-deficiennt mouse developing eye.
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined.
adaptor-related protein complex 2, alpha 1 subunit
, daptor-related protein complex 2, alpha 2 subunit
, adaptor protein complex AP-2, alpha 1 subunit
, AP-2 complex subunit alpha-1-like
, AP-2 complex subunit alpha-1
, 100 kDa coated vesicle protein A
, adapter-related protein complex 2 alpha-1 subunit
, adaptin, alpha A
, adaptor protein complex AP-2 subunit alpha-1
, alpha-adaptin A
, clathrin assembly protein complex 2 alpha-A large chain
, clathrin-associated/assembly/adaptor protein, large, alpha 1
, plasma membrane adaptor HA2/AP2 adaptin alpha A subunit
, adaptor-related protein complex AP-2, alpha 1 subunit