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Browse our CRB2 Proteins (CRB2)

Full name:
Crumbs Homolog 2 (Drosophila) Proteins (CRB2)
On www.antibodies-online.com are 4 Crumbs Homolog 2 (Drosophila) (CRB2) Proteins from 1 different suppliers available. Additionally we are shipping CRB2 Antibodies (25) and many more products for this protein. A total of 31 CRB2 products are currently listed.
Synonyms:
5930402A21, BC043114
list all proteins Gene Name GeneID UniProt
CRB2 241324 Q80YA8
CRB2 286204 Q5IJ48

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CRB2 Proteins (CRB2) by Origin

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More Proteins for CRB2 Interaction Partners

Mouse (Murine) Crumbs Homolog 2 (Drosophila) (CRB2) interaction partners

  1. Our study identified CRB2 as the member of the CRB protein family that is present together with the rest of the components of the Crumbs complex in the RPE (show RPE Proteins) apico-lateral cell membrane.

  2. Here we show that mouse POGLUT1 (show POGLUT1 Proteins) modifies NOTCH1 (show NOTCH1 Proteins) in vivo; however, the essential role of POGLUT1 (show POGLUT1 Proteins) in gastrulation is due to POGLUT1 (show POGLUT1 Proteins)-dependent glycosylation of EGF (show EGF Proteins) repeats in the apical polarity protein CRUMBS2

  3. Study showed that CRB1 (show CRB1 Proteins) and CRB2 in human retinas have an opposite pattern of expression in Muller glia and photoreceptor cells compared with mouse retinas, and that Crb2 influences the severity of the murine Crb1 (show CRB1 Proteins)-linked retinal dystrophies.

  4. Data suggest that short-term loss of CRB2 in adult mouse photoreceptors, but not in Muller glial cells, causes sporadic loss of adhesion between photoreceptors and Muller cells

  5. These findings suggest that CRB1 (show CRB1 Proteins) and CRB2 suppress late progenitor pool expansion by regulating multiple proliferative signaling pathways.

  6. loss of CRB2 in the developing retina results in retinal disorganization and subsequent degeneration without major changes in the transcriptome of the retina.

  7. data suggest an essential role for CRB2 in proper lamination of the photoreceptor layer and suppression of proliferation of late-born retinal progenitor cells

  8. Data show the deletion of Pals1 (show MPP5 Proteins) leads to the disruption of the apical localization of Crb polarity complex proteins Crb1 (show CRB1 Proteins), Crb2 and Crb3 (show CRB3 Proteins) in retinal progenitors and the adult retina.

  9. Deficiency in Crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice.

  10. demonstrate that Crb2 overexpression under self-renewing conditions increases glycogen synthase kinase (GSK)-3beta inhibition

Human Crumbs Homolog 2 (Drosophila) (CRB2) interaction partners

  1. We demonstrate that CRB2 mutations result in loss of function and therefore constitute causative mutations leading to Nephrotic syndrome in humans.

  2. The three families with six affected individuals present compelling evidence for the role of CRB2 in human disease, with a phenotype comprising severe, congenital neurological and renal involvement.

  3. Study showed that CRB1 (show CRB1 Proteins) and CRB2 in human retinas have an opposite pattern of expression in Muller glia and photoreceptor cells compared with mouse retinas, and that Crb2 influences the severity of the murine Crb1 (show CRB1 Proteins)-linked retinal dystrophies.

  4. results suggest that CRB2 functions as an inhibitory binding protein that is involved in the formation of a mature but inactive pool of the gamma-secretase complex

  5. The CRB2 gene encodes a transmembrane protein (1285 aa) and a secreted protein (1176 aa). The transmembrane isoform consists of 14 extracellular EGF-like domains, 3 extracellular laminin G-like domains, and a Crb cytoplasmic tail domain.

  6. This study shows that CRB2 sequence variants are not a common cause of autosomal recessive RP and LCA (show CLTA Proteins).

  7. Using X-ray crystallography and NMR spectroscopy, we show that, despite low amino acid sequence conservation, both 53BP1 and Crb2 contain tandem tudor domains that interact with histone H4 specifically dimethylated at Lys20 (H4-K20me2).

  8. overexpression of human CRB1 (show CRB1 Proteins) and related isoforms, CRB2 and CRB3 (show CRB3 Proteins), had no effect on the levels of presenilin complex components, on NCT (show NCSTN Proteins) maturation or on PS endoproteolysis

CRB2 Protein Profile

Protein Summary

May play a role in polarized cells morphogenesis.

Alternative names and synonyms associated with CRB2

  • crumbs homolog 2 (Drosophila) (Crb2)
  • crumbs homolog 2 (Drosophila) (CRB2)
  • 5930402A21 protein
  • BC043114 protein

Protein level used designations for CRB2

crumbs-like protein 2 , protein crumbs homolog 2

GENE ID SPECIES
241324 Mus musculus
286204 Homo sapiens
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