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pre-coated Notch1 (show NOTCH1 ELISA Kits) protein promotes Notch1 (show NOTCH1 ELISA Kits)-knocked down B cells to produce antibody in LPS (show TLR4 ELISA Kits)-stimulated B cells suggesting that Notch1 (show NOTCH1 ELISA Kits) in other cells may promote antibody production by binding its ligands Dll1 and Jag1 (show JAG1 ELISA Kits) in B cells.
Hedgehog (show SHH ELISA Kits)/Patched (show PTCH1 ELISA Kits)-associated rhabdomyosarcoma formation from delta1-expressing mesodermal cells
the effects of two Notch (show NOTCH1 ELISA Kits) ligands, i.e., Jagged1 (show JAG1 ELISA Kits) and DLL1, on murine and human hematopoiesis in vitro. Our observations indicate that the stromal expression of Notch (show NOTCH1 ELISA Kits) ligands increases the production of both the total and phenotypically early murine and human hematopoietic cells in the co-culture.
Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
the structural integrity of each individual EGF (show EGF ELISA Kits) repeat in the extracellular domain of DLL1 is necessary for full DLL1 activity
A novel mouse xenograft model to study the role of TSLP (show TSLP ELISA Kits)-induced CRLF2 (show CRLF3 ELISA Kits) signals in normal and malignant human B lymphopoiesis has been developed.
High-cholesterol diet increased TSLPR (show CRLF2 ELISA Kits) expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR (show CRLF2 ELISA Kits), potentially through the PI3K/Akt (show AKT1 ELISA Kits) signal pathway.
Role of Dll1 in embryogenesis and notch (show NOTCH1 ELISA Kits) signaling.
the appropriate timing of Dll1 expression is critical for the oscillatory networks and suggest the functional significance of oscillatory cell-cell interactions in tissue morphogenesis
Activating thymic stromal lymphopoietin (show TSLP ELISA Kits) promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR (show CRLF2 ELISA Kits) signaling in a mouse model.
Highly methylated domains containing a putative fetal brain enhancer near DLL1 was found to reach genome-wide significance and was validated for significantly higher methylation in autism spectrum disorders children than in controls.
The DLK1 (show DLK1 ELISA Kits) inhibited the odontoblastic differentiation of hDPSCs, which maybe through ERK (show EPHB2 ELISA Kits) signalling pathway.
DLL1-mediated Notch (show NOTCH1 ELISA Kits) signaling is critical for proper bone remodeling as it regulates the differentiation and function of both osteoblasts and osteoclasts.
Human Jagged-1 induced the proliferation and differentiation of CD133+ cord blood progenitors compared with hDll-1. Thus, hJagged-1 signaling in the bone marrow niche may be used to expand EPCs for therapeutic angiogenesis
Gain-of-function and loss-of-function studies demonstrated that miR (show MLXIP ELISA Kits)-130b-3p could inhibit breast carcinoma cell invasion and migration by directly targeting the Notch ligand (show JAG2 ELISA Kits) Delta-like 1 (DLL1).
Mir (show MLXIP ELISA Kits)-34a functions as a regulator by decreasing the expression of NOTCH1 (show NOTCH1 ELISA Kits) and DLL1. Our study is the first to identify a correlation between mir (show MLXIP ELISA Kits)-34a and its target genes NOTCH1 (show NOTCH1 ELISA Kits) and DLL1 in endometrial adenocarcinoma
High DLL1 levels were associate with reduced exercise capacity and diastolic dysfunction in chronic heart failure patients.
Although Delta1 activates signal transducer and activator of transcription 3 (show STAT3 ELISA Kits) signaling similarly to the gp130 (show IL6ST ELISA Kits)-activating cytokine interleukin-6 (IL-6 (show IL6 ELISA Kits)), it has opposite effects on myeloid cell production.
Notch ligand (show JAG2 ELISA Kits) Dll1 may enhance the adhesion and metastasis of melanoma cells by upregulation of N-cadherin (show CDH2 ELISA Kits).
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.
delta-like 1 (Drosophila)
, TSLP receptor
, cytokine receptor-like molecule 2
, delta 1
, lymphocyte antigen 114
, thymic stromal lymphopoietin protein receptor
, thymic stromal-derived lymphopoietin, receptor
, transmembrane phosphoinositide 3-phosphatase and tensin homolog 2
, type I cytokine receptor delta 1
, delta-like protein 1
, drosophila Delta homolog 1
, delta like-1
, delta-like 1