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Browse our LFNG Proteins (LFNG)

Full name:
LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase Proteins (LFNG)
On www.antibodies-online.com are 10 LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) Proteins from 3 different suppliers available. Additionally we are shipping LFNG Antibodies (61) and LFNG Kits (20) and many more products for this protein. A total of 95 LFNG products are currently listed.
Synonyms:
AW061165, id:ibd2614, id:ibd5029, id:ibd5138, l-fng, SCDO3, wu:fc69h02, wu:fi34c01
list all proteins Gene Name GeneID UniProt
LFNG 3955 Q8NES3
LFNG 16848 O09010
LFNG 170905 Q924T4

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Human LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) interaction partners

  1. LFNG expression correlates with expansion of cancer stem cell populations and NKX3.1 (show NKX3-1 Proteins) expression in human prostate cancer.

  2. Reduced LFNG expression facilitates JAG/NOTCH (show NOTCH1 Proteins) luminal progenitor signaling and cooperates with MET/CAVEOLIN basal-type signaling to promote basal-like breast cancer.

  3. Mutation of the LFNG gene causes spondylocostal dysostosis with a severe vertebral phenotype, reinforcing the hypothesis that proper regulation of the Notch (show NOTCH1 Proteins) signaling pathway is an absolute requirement for the correct patterning of the axial skeleton.

Mouse (Murine) LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) interaction partners

  1. LFNG protein may have context-dependent effects on Notch (show NOTCH1 Proteins) activity; somitogenesis is disrupted by a novel dominant allele of Lfng

  2. Lfng expression and activity is normal in mice whose Lfng is lengthened by 10 kb, and no effects on segmentation are evident.

  3. suggest that modulation of the Notch (show NOTCH1 Proteins) signaling by Lfng affects the clock period during development

  4. STAT5 (show STAT5A Proteins)-dependent amplification of Notch (show NOTCH1 Proteins)-modifying Lfng augments Th2 response via Dll4 (show DLL4 Proteins) and is critical for amplifying viral exacerbation during allergic airway disease.

  5. The repressive effect of Lfng against Notch (show NOTCH1 Proteins) activities in neighbouring cells can sufficiently explain the synchronization in vivo.

  6. Intriguing changes are observed in the cranio-caudal borders of multifidus muscle in mutant Dll3 (show DLL3 Proteins) and Lfng models of idiopathic scoliosis.

  7. Reduced LFNG expression facilitates JAG/NOTCH (show NOTCH1 Proteins) luminal progenitor signaling and cooperates with MET/CAVEOLIN basal-type signaling to promote basal-like breast cancer.

  8. the presence of Gal (show GAL Proteins) on O-fucose glycans differentially affects DLL1 (show DLL1 Proteins)-induced NOTCH (show NOTCH1 Proteins) signaling modulated by LFNG versus MFNG (show MFNG Proteins)

  9. Decreasing Lfng expression during the (TCR-CD4 (show CD4 Proteins)/CD8 (show CD8A Proteins) double negative 3) DN3-DP (CD4 (show CD4 Proteins)/CD8 (show CD8A Proteins) double positive) transition minimizes the potent leukemogenic potential of Notch1 (show NOTCH1 Proteins) signaling.

  10. data reveal that Lfng enhances CD4 (show CD4 Proteins)/CD8 (show CD8A Proteins) double-negative 3b precursor competition for intrathymic Delta-like (show DLK1 Proteins) Notch (show NOTCH1 Proteins) ligands to maximize Notch (show NOTCH1 Proteins)-induced clonal expansion during the earliest stage of beta-selection.

Zebrafish LFNG O-Fucosylpeptide 3-beta-N-Acetylglucosaminyltransferase (LFNG) interaction partners

  1. lfng regulates delta-notch (show NOTCH1 Proteins) induction of hypochord.

  2. The sequence and embryonic expression of lfng were studied.

  3. Lfng acts in a feedback loop downstream of proneural genes.

LFNG Protein Profile

Protein Summary

This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with LFNG

  • LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (LFNG)
  • lunatic fringe (LOC100218383)
  • LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase (Lfng)
  • lunatic fringe (lfng)
  • lunatic fringe homolog (lfng)
  • AW061165 protein
  • id:ibd2614 protein
  • id:ibd5029 protein
  • id:ibd5138 protein
  • l-fng protein
  • SCDO3 protein
  • wu:fc69h02 protein
  • wu:fi34c01 protein

Protein level used designations for LFNG

lunatic fringe , beta-1,3-N-acetylglucosaminyltransferase lunatic fringe , O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase , lunatic fringe gene homolog , lunatic fringe homolog

GENE ID SPECIES
100012518 Monodelphis domestica
100218383 Taeniopygia guttata
3955 Homo sapiens
516209 Bos taurus
16848 Mus musculus
170905 Rattus norvegicus
395790 Gallus gallus
101112372 Ovis aries
397855 Xenopus laevis
30158 Danio rerio
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