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Low levels of Notch pathway genes Notch1, Notch2, Notch4 and Jagged1 correlated with poor prognostic factors such as larger tumor size, positive lymph-node status, tumor phenotype and infiltrating tumor Treg cells.
Data suggest that the vascular DLL4-Notch4 signaling and VEGF signaling complementing each other plays an important role in the progression of tumor angiogenesis in primary glioblastoma.
findings indicate that Notch4+ melanoma cancer stem-like cells trigger epithelial-mesenchymal transition and promote the metastasis of melanoma cells
the aberrant activation of Notch4 promotes oral squamous cell carcinoma metastasis.
High Notch4 expression is associated with Prostatic Intraepithelial Neoplasia.
The expression of cytoplasmic Notch1 (show NOTCH1 Proteins) or nuclear Notch4 could also be upregulated by HBx in HepG2X cells. The upregulation of Notch1 (show NOTCH1 Proteins) by HBx was through p38 MAPK (show MAPK14 Proteins) pathway.
Anti-estrogen resistance in human breast tumors is driven by JAG1 (show JAG1 Proteins)-NOTCH4-dependent cancer stem cell activity.
Notch 3 (show NOTCH3 Proteins) and 4, and not Notch 1 (show NOTCH1 Proteins), were highly increased in human arteriovenous malformations.
NOTCH4 polymorphism can influence clinical symptoms in Slovenian patients with schizophrenia.
Our findings provide a novel mechanism for Notch4-ICD (show GNPTAB Proteins) regulation, suggesting a negative regulatory role for the PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins) pathway in Notch4 nuclear signaling.
Report impaired Notch4 signaling in endothelial progenitor cells isolated from mouse Kawasaki disease model.
Notch4-knock-out mice that also lacked Notch1 (show NOTCH1 Proteins), had defects in all vascular beds.
Relative to air-exposed controls, ozone increased bronchoalveolar lavage fluid protein, a marker of lung permeability, in all genotypes, but significantly greater concentrations were found in Notch4-/- compared with wild-type and Notch3 (show NOTCH3 Proteins)-/- mice.
Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.
Notch (show NOTCH1 Proteins) signaling is required for proper lymphatic valve formation and regulates integrin alpha9 and fibronectin (show FN1 Proteins) EIIIA expression during valve morphogenesis
Notch4-deficient mice exhibited slightly delayed vessel growth in the retina, consistent with the novel finding that NOTCH4 protein is expressed in the newly formed vasculature.
Data indicate that expression of Dll4 (show DLL4 Proteins) is specific to theca layer endothelial cells (ECs); Notch1 (show NOTCH1 Proteins)/Notch4 in theca layer ECs and vascular smooth muscle cells (VSMCs), Notch3 (show NOTCH3 Proteins) is restricted to VSMCs; Notch2 (show NOTCH2 Proteins) in granulosa cells (GCs (show UGCG Proteins)) of small follicles.
In this study, we examined Notch (show NOTCH1 Proteins) signaling in the well established Tg26 mouse model of HIV associated nephropathy.
Notch4 normalization reduces blood vessel size in arteriovenous malformations
results demonstrate that whey acidic protein (show Wap Proteins) promoter-Int3 has no oncogenic effect upon parity-identified mammary epithelial cells
This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.
, neurogenic locus notch homolog protein 4-like
, Notch homolog 4
, Notch homolog 4 (Drosophila)
, neurogenic locus notch homolog protein 4
, Notch gene homolog 4