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Human Monoclonal NR0B1 Primary Antibody for ICC, IF - ABIN2668705
Battista, Otis, Côté, Laforest, Peter, Lalli, Gallo-Payet: Extracellular matrix and hormones modulate DAX-1 localization in the human fetal adrenal gland. in The Journal of clinical endocrinology and metabolism 2005
Show all 2 Pubmed References
The proximity of the expression of dax1 to 5th branchial arch and numerous known tooth markers led us to hypothesize that dax1 is involved in pharyngeal tooth development in the zebrafish.
Nonsense mutation in the DAX-1 gene is associated with precocious puberty and late-onset hypogonadotropic hypogonadism.
These findings suggested that the mutation of NR0B1 in X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism enhanced the function of DAX1 to repress SF-1 (show NR5A1 Antibodies) activation, while DAX1 is expected to have additional roles in the pathological mechanism.
DAX1 and SF1 (show NR5A1 Antibodies) expression positively correlated in pediatric adrenocortical tumors, suggesting that these transcription factors might cooperate in adrenocortical tumorigenesis.
This novel mutation (p. V385L) of DAX-1 is the first to be identified in association with secretory azoospermia, thereby highlighting the important role of DAX-1 in spermatogenesis.
DAX-1 is less specific than Ap2beta (show AP2B1 Antibodies), however it is a sensitive marker for translocation positive ARMS and can be helpful in their diagnosis if used in combination with Ap2beta (show AP2B1 Antibodies)
DAX1 mutations were associated with X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism.
Case Report: novel mutation in the NR0B1 (DAX1) gene in a large family with two boys affected by congenital adrenal hypoplasia.
DAX-1 protein is necessary to maintain normal spermatogenesis. In humans, male fertility has been studied in few patients carrying DAX-1 mutations. Review.
results suggest a previously unknown DAX-1/beta-Catenin (show CTNNB1 Antibodies) molecular network controlling HCC (show FAM126A Antibodies) development
Two Taiwanese patients with adrenal hypoplasia congenita were detected to have novel mutations of the DAX1 (NR0B1) gene.
Findings indicate that the Gata6 (show GATA6 Antibodies) promoter is activated by Esrrb in association with Ncoa3 (show NCOA3 Antibodies), and Dax1 inhibited activities of Esrrb and Ncoa3 (show NCOA3 Antibodies), resulting maintenance of the undifferentiated status of embryonic stem (ES) cells.
Data indicate that nuclear receptor subfamily 0 group B member 1 (Nr0b1) interacted with androgen receptor (AR (show AR Antibodies)) in Sertoli cells (SCs (show TWIST1 Antibodies)).
Nr0b1 is a negative regulator of Zscan4c in mouse embryonic stem cells
Dax1 and Nanog have roles in stabilizing mouse embryonic stem cells and induced pluripotency
Here we review the current knowledge on properties, functions and mechanisms of DAX1 action.
Insulin (show INS Antibodies)-mediated induction of DAX-1 in Leydig cells of testis may be a key regulatory step of serum sex hormone level in insulin (show INS Antibodies)-resistant states.
Dax1 functions as a negative regulator of Esrrb and Oct3/4 (show POU5F1 Antibodies), and these molecules form a regulatory loop for controlling the pluripotency and self-renewal capacity of embryonic stem cells.
Transcriptional differences between mouse embryonic and epiblast stem cells is mediated through a Sox2 (show SOX2 Antibodies)/Esrrb heterodimer regulating Nr0b1.
Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD (show FADS1 Antibodies)) in mice by inhibiting steroidogenic factor-1 (SF1 (show NR5A1 Antibodies)) activation of the testis enhancer of SRY-box-9 (Sox9 (show SOX9 Antibodies)).
overexpression of DAX-1 had no effect on the retinoic acid-induced differentiation of P19 (show CDKN2D Antibodies) cells to either endodermal or neuronal cells
Involvement of Ad4BP/SF-1 (show NR5A1 Antibodies), DAX-1, and COUP-TFII (show NR2F2 Antibodies) transcription factor on steroid production and luteinization in ovarian theca cells.
the decrease of Dax-1 transcription factor and the increase in histone H3 (show HIST3H3 Antibodies) acetylation may play important roles in progesterone synthesis in luteinizing granulosa cells.
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
, nuclear receptor subfamily 0 group B member 1
, nuclear receptor subfamily 0, group B, member 1
, orphan nuclear receptor DAX-1
, DSS-AHC critical region on the X chromosome, gene 1
, DSS-AHC critical region on the X chromosome protein 1
, nuclear hormone receptor
, nuclear receptor DAX-1
, nuclear receptor DAX1
, adrenal hyoplasia protein DAX1
, adrenal hypoplasia congenital
, adrenal hypoplasia congenita-like protein
, adrenal hypoplasia, congenital homolog