anti-Human PTPN6 antibody for Immunofluorescence

Recommended PTPN6 Antibody (supplied by: Log in to see )

Antigen
Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
  • SHP
  • SHP-1
  • Shp1
  • HCP
  • HCPH
  • HPTP1C
  • PTP-1C
  • SH-PTP1
  • SHP-1L
  • SHP1
  • Hcph
  • Ptp1C
  • hcp
  • me
  • motheaten
  • Ptph6
  • Shp-1
  • DRPLA
  • protein tyrosine phosphatase, non-receptor type 6
  • nuclear receptor subfamily 0, group B, member 2
  • PTPN6
  • Nr0b2
  • Ptpn6
Epitope
AA 492-597
26
24
15
10
8
6
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
204
90
85
6
3
2
2
2
1
1
1
1
1
Host
Mouse
133
39
33
Clonality
Monoclonal
Conjugate
This PTPN6 antibody is un-conjugated
8
8
7
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
148
84
58
35
35
29
17
10
8
6
5
4
2
1
Options
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Catalog No. ABIN967766
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
12.14905 ABIN967767 IF IP IHC WB Mouse IgG1 AA 492-597 Log in to see 52-PTP1C-SHP1 5
12.14905 ABIN1882123 IF IHC (p) WB Rabbit AA 247-277, Center Log in to see Polyclonal 2
12.14905 ABIN4348608 ICC IF IHC IHC (p) WB Rabbit IgG Log in to see Polyclonal 1
12.14905 ABIN1870549 IF IHC Rabbit IgG pTyr536 Log in to see Polyclonal
12.14905 ABIN1874455 IF IHC WB Rabbit IgG Log in to see Polyclonal
12.14905 ABIN2404230 IF IHC WB Rabbit IgG Log in to see Polyclonal
12.14905 ABIN3020460 IF IHC Rabbit pTyr536 Log in to see Polyclonal
1 ABIN197592 IF IHC (p) WB Rabbit Tyr536 Log in to see Polyclonal 4
1 ABIN319255 IF IHC (p) Rabbit pTyr536 Log in to see Polyclonal 4
1 ABIN363036 IF IHC WB Rabbit IgG AA 534-538 Log in to see Polyclonal 2
1 ABIN362408 IF IHC Rabbit IgG pTyr536 Log in to see Polyclonal 4
1 ABIN114550 EIA IHC (fro) IF WB Mouse IgG1 Log in to see PTY6
1 ABIN114551 EIA IHC (fro) IF WB Mouse IgG2a Log in to see PTY10
1 ABIN2882770 IF IHC Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN1842510 IF IHC WB Rabbit IgG pTyr536 Log in to see Polyclonal
1 ABIN452174 EIA IHC (fro) IF WB Mouse IgG1 Log in to see PTY11
1 ABIN452175 EIA IHC (fro) IF WB Mouse IgG1 Log in to see PTY15
1 ABIN5531900 IF IHC (p) WB Rabbit Ig Fraction AA 247-277 Log in to see Polyclonal
1 ABIN2888224 IF IHC WB Rabbit IgG Log in to see Polyclonal
1 ABIN1959784 IF IHC (p) Rabbit pTyr536 Log in to see Polyclonal

General

Antigen Protein-tyrosine Phosphatase 1C (PTPN6) Antibodies
Epitope AA 492-597
(26), (24), (15), (10), (8), (6), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
(204), (90), (85), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Host Mouse
(133), (39), (33)
Clonality (Clone)
Monoclonal   ( )
Conjugate This PTPN6 antibody is un-conjugated
(8), (8), (7), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(148), (84), (58), (35), (35), (29), (17), (10), (8), (6), (5), (4), (2), (1)
Pubmed 5 references available
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Product Details anti-PTPN6 Antibody

Target Details PTPN6 Application Details Handling References for anti-PTPN6 antibody (ABIN967766) Images
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine)
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human PTP1C aa.. 492-597
Clone 52-PTP1C-SHP1
Isotype IgG1

Target Details PTPN6

Product Details anti-PTPN6 Antibody Application Details Handling References for anti-PTPN6 antibody (ABIN967766) Images back to top
Antigen
Alternative Name PTP1C (PTPN6 Antibody Abstract)
Background PTP1C (SH-PTP1, SHP-1, or HCP) is a protein-tyrosine phosphatase (PTP) that is expressed in epithelial and hematopoietic cells. It contains two N-terminal SH2 domains and a C-terminal phosphatase domain. While its distribution is primarily cytosolic, exposure to various stimuli induces movement of PTP1C to other cellular locations to allow interaction with its substrates. This enzyme associates with the IL-3, IL-4, erythropoietin, and stem cell factor receptors and may regulate their signaling pathways by dephosphorylation of their receptors or their downstream effectors. Motheaten mice, which possess a nonfunctional PTP1C gene, display multiple hematopoietic abnormalities including increased proliferation and activation of myeloid cells. Studies involving these mice have clearly implicated PTP1C in negative regulation of CSF-1 (colony stimulating factor-1) mitogenic signaling and have demonstrated a role for PTP1C as an intermediate between Ras and the MAP kinase pathway.
Molecular Weight 68 kDa
Pathways JAK-STAT Signaling, TCR Signaling, TLR Signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2

Application Details

Product Details anti-PTPN6 Antibody Target Details PTPN6 Handling References for anti-PTPN6 antibody (ABIN967766) Images back to top
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details References for anti-PTPN6 antibody (ABIN967766) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20° C.

References for anti-PTPN6 antibody (ABIN967766)

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Handling Images back to top
Product cited in:

Duchene, Schanstra, Pecher, Pizard, Susini, Esteve, Bascands, Girolami: "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40375-83, 2002

Keilhack, Müller, Böhmer, Frank, Weidner, Birchmeier, Ligensa, Berndt, Kosmehl, Günther, Müller, Birchmeier, Böhmer: "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1." in: The Journal of cell biology, Vol. 152, Issue 2, pp. 325-34, 2001

Lund-Johansen, Davis, Bishop, de Waal Malefyt: "Flow cytometric analysis of immunoprecipitates: high-throughput analysis of protein phosphorylation and protein-protein interactions." in: Cytometry, Vol. 39, Issue 4, pp. 250-9, 2000

Liu, Hill, Chernoff: "Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)." in: The Journal of biological chemistry, Vol. 271, Issue 49, pp. 31290-5, 1997

Kenner, Anyanwu, Olefsky, Kusari: "Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-I-stimulated signaling." in: The Journal of biological chemistry, Vol. 271, Issue 33, pp. 19810-6, 1996

Images

Product Details anti-PTPN6 Antibody Target Details PTPN6 Application Details Handling References for anti-PTPN6 antibody (ABIN967766) back to top
Supplier Images
Western Blotting (WB) image for anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 492-597) antibody (ABIN967766) Western blot analysis of PTP1C on Jurkat cell lysate. Lane 1: 1:500, lane 2: 1:1000, ...
Immunofluorescence (IF) image for anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 492-597) antibody (ABIN967766) Immunofluorescent staining on HL60 cells.