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|Application / Reactivity||Human||Mouse (Murine)||Rat (Rattus)|
|Western Blotting (WB)||284 Antibodies||102 Antibodies||86 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Immunostaining (ISt)||1 Antibodies|
|Immunoprecipitation (IP)||71 Antibodies||44 Antibodies||27 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||63 Antibodies||21 Antibodies||17 Antibodies|
|Immunohistochemistry (IHC)||121 Antibodies||54 Antibodies||51 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||8 Antibodies||5 Antibodies||2 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||1 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||2 Antibodies|
|Antigen||BCL2-Associated X Protein (BAX) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This BAX antibody is un-conjugated Alternatives|
Flow Cytometry (FACS)
|9 references available|
|Supplier||Log in to see|
Product Details anti-BAX AntibodyTarget Details BAX Application Details Handling References for anti-BAX Antibody (ABIN2664009) Images
|Purification||This antibody was purified by affinity chromatography.|
Target Details BAXProduct Details anti-BAX Antibody Application Details Handling References for anti-BAX Antibody (ABIN2664009) Images back to top
|Alternative Name||Bax (BAX Antibody Abstract)|
|Background||Bax is a 21 kD pro-apoptotic protien known to regulate apoptosis. Bax is found in the cytoplasm, mitochondria, and nucleus and is highly expressed in hematopoietic stem cells, the ovary, and in the lymph node. Bax binds the anti-apoptotic protein Bcl-2 as a heterodimer or forms homodimers. The relative levels of pro-apoptotic proteins such as Bax and anti-apoptotic proteins such as Bcl-2 determines whether cell death will occur following an apoptotic stimulus. Bax accelerates the opening of mitochondrial VDAC altering membrane potential and allowing cytochrome c to pass out of the mitochondria into the cytosol to initiate downstream caspase activation. p53 can transcriptionally activate the Bax gene to induce apoptosis. Bax has been shown to be mutated in some human cancers. The Poly6251 antibody has been reported to be useful for Western blotting, immunoprecipitation, and immunohistochemistry of human, mouse, and rat Bax protein.|
|Research Area||Cancer, Apoptosis/Necrosis|
|Pathways||p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis|
Application DetailsProduct Details anti-BAX Antibody Target Details BAX Handling References for anti-BAX Antibody (ABIN2664009) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-BAX Antibody Target Details BAX Application Details References for anti-BAX Antibody (ABIN2664009) Images back to top
|Buffer||phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % gelatin.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-BAX Antibody (ABIN2664009)Product Details anti-BAX Antibody Target Details BAX Application Details Handling Images back to top
Hayashida, Kajino, Hattori et al.: "MDM2 regulates a novel form of incomplete neoplastic transformation of Theileria parva infected lymphocytes." in: Experimental and molecular pathology, Vol. 94, Issue 1, pp. 228-38, 2013 (PubMed).
Leroy, Tricot, Lacour et al.: "Protective effect of eicosapentaenoic acid on palmitate-induced apoptosis in neonatal cardiomyocytes." in: Biochimica et biophysica acta, Vol. 1781, Issue 11-12, pp. 685-93, 2008 (PubMed).
Ma, Hossain, Chow et al.: "Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia." in: Annals of neurology, Vol. 58, Issue 2, pp. 182-93, 2005 (PubMed).
Kim, Seong, Kim: "Enhancement of tumor response by farnesyltransferase inhibitor in C3H/HeJ hepatocarcinoma." in: Annals of the New York Academy of Sciences, Vol. 1030, pp. 95-102, 2005 (PubMed).
You, Seo, Chung et al.: "A novel metalloprotease from Gloydius halys venom induces endothelial cell apoptosis through its protease and disintegrin-like domains." in: Journal of biochemistry, Vol. 134, Issue 5, pp. 739-49, 2003 (PubMed).
LeBlanc, Lawrence, Varfolomeev et al.: "Tumor-cell resistance to death receptor--induced apoptosis through mutational inactivation of the proapoptotic Bcl-2 homolog Bax." in: Nature medicine, Vol. 8, Issue 3, pp. 274-81, 2002 (PubMed).
Marzo, Brenner, Zamzami et al.: "Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis." in: Science (New York, N.Y.), Vol. 281, Issue 5385, pp. 2027-31, 1998 (PubMed).
Oltvai, Milliman, Korsmeyer: "Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death." in: Cell, Vol. 74, Issue 4, pp. 609-19, 1993 (PubMed).
Miyashita, Reed: "Tumor suppressor p53 is a direct transcriptional activator of the human bax gene." in: Cell, Vol. 80, Issue 2, pp. 293-9, 1995 (PubMed).
ImagesProduct Details anti-BAX Antibody Target Details BAX Application Details Handling References for anti-BAX Antibody (ABIN2664009) back to top