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anti-Human MRPL41 Antibodies:
anti-Mouse (Murine) MRPL41 Antibodies:
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Human Monoclonal MRPL41 Primary Antibody for IHC, IHC (p) - ABIN4345524
Herraiz, Calvo, Pandya, Cantelli, Rodriguez-Hernandez, Orgaz, Kang, Chu, Sahai, Sanz-Moreno: Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination. in Journal of the National Cancer Institute 2015
our data suggest that high expression of p53 (show TP53 Antibodies)-inducible gene 3 is significant for glioblastoma inhibition and p53 (show TP53 Antibodies)-inducible gene 3 independently indicates good prognosis in patients, which might be a novel prognostic biomarker or potential therapeutic target in glioblastoma.
Data indicate that knockdown of p53 (show TP53 Antibodies)-induced gene 3 (PIG-3) expression by small interfering RNA (siRNA) treatment can inhibit the generation of reactive oxygen species (ROS (show ROS1 Antibodies)).
The results suggested that PIG3 plays an oncogenic role in PTC (show F9 Antibodies) via the regulation of the PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies)/PTEN (show PTEN Antibodies) pathway and support the exploration of PIG3 as a novel biomarker for patients with papillary thyroid carcinoma
PIG3, which functions in DNA damage repair, uses an unexpected catalytic mechanism to suppress Rho-ROCK activity and impair tumor invasion in vivo. This regulation was suppressed by antioxidants.
Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor (show ESR1 Antibodies) status in breast cancer.
prohibitin (show PHB Antibodies) and prohibiton (PHB2 (show PHB2 Antibodies)) contribute to PIG3-mediated apoptosis by binding to the PIG3 promoter (TGYCC)15 motif
study provides evidence that the variant genotypes of (TGYCC)n repeats in the PIG3 promoter are functional and associated with risk of squamous cell carcinoma of the head and neck in a non-Hispanic white population
Apoptosis-inducing ability of wild-type BMRP is blocked by Bcl-2 (show BCL2 Antibodies) through several mechanisms.
a novel signaling pathway of GPx3 (show GPX3 Antibodies)-PIG3 in the regulation of cell death in prostate cancer.
region of BMRP required for the interaction with Bcl-2 (show BCL2 Antibodies) is very relevant for the cell death-inducing activity of the protein
The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, 39S ribosomal protein L41, mitochondrial
, mitochondrial ribosomal protein L41
, 39S ribosomal protein L27 homolog
, MRP-L27 homolog
, bcl-2-interacting mitochondrial ribosomal protein L41
, cell proliferation-inducing gene 3 protein
, proliferation-inducing gene 3
, p53-induced gene 3 protein
, quinone oxidoreductase PIG3
, quinone oxidoreductase homolog