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|Application / Reactivity||Mouse (Murine)||Human|
|ELISA||8 Antibodies||41 Antibodies|
|Flow Cytometry (FACS)||2 Antibodies||13 Antibodies|
|Immunocytochemistry (ICC)||5 Antibodies||10 Antibodies|
|Immunofluorescence (IF)||4 Antibodies||12 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||1 Antibodies||1 Antibodies|
|Immunohistochemistry (IHC)||9 Antibodies||20 Antibodies|
|Immunoprecipitation (IP)||1 Antibodies|
|Western Blotting (WB)||17 Antibodies|
|Dot Blot (DB)||4 Antibodies|
|ELISA (Capture)||1 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Immunoassay (IA)||1 Antibodies|
|Immunochromatography (IC)||2 Antibodies|
|Antigen||Twist Homolog 1 (Drosophila) (TWIST1) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This TWIST1 antibody is un-conjugated Alternatives|
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-TWIST1 AntibodyTarget Details TWIST1 Application Details Handling References for anti-TWIST1 Antibody (ABIN2668516) Images
|Purification||Protein G Chromatography|
|Immunogen||This TWIST antibody was raised against a recombinant protein corresponding to full-length mouse TWIST.|
Target Details TWIST1Product Details anti-TWIST1 Antibody Application Details Handling References for anti-TWIST1 Antibody (ABIN2668516) Images back to top
|Alternative Name||TWIST (TWIST1 Antibody Abstract)|
|Background||TWIST is a regulator of transcription that serves as a master regulator of embryonic morphogenesis. Through its bHLH motif it interacts with many different transcription factors to affect multiple pathways of gene expression. TWIST plays a pivotal role in mesodermal, myoblast, and osteoblast differentiation. TWIST is involved in the epithelial-mesenchymal transition (EMT), a period during embryonic development characterized by loss of cell adhesion and increased cell mobility, essential events for mesoderm and neural tube formation. The EMT shares many features of metastatic cancer, and elevated levels of TWIST are observed in many types of cancer. Mutations in the gene encoding TWIST have been associated with Saethre- Chotzen syndrome, an an inherited developmental disorder characterized by skull deformations, limb abnormalities, and facial dysmorphisim.|
|Molecular Weight||21 kDa|
Application DetailsProduct Details anti-TWIST1 Antibody Target Details TWIST1 Handling References for anti-TWIST1 Antibody (ABIN2668516) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TWIST1 Antibody Target Details TWIST1 Application Details References for anti-TWIST1 Antibody (ABIN2668516) Images back to top
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
|Storage Comment||Antibodies in solution can be stored at -80 °C for 2 years.|
|Expiry Date||6 months|
References for anti-TWIST1 Antibody (ABIN2668516)Product Details anti-TWIST1 Antibody Target Details TWIST1 Application Details Handling Images back to top
|Product cited in:||
Ezponda, Popovic, Shah et al.: "The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer." in: Oncogene, Vol. 32, Issue 23, pp. 2882-90, 2013 (PubMed).
Eckert, Lwin, Chang et al.: "Twist1-induced invadopodia formation promotes tumor metastasis." in: Cancer cell, Vol. 19, Issue 3, pp. 372-86, 2011 (PubMed).
Casas, Kim, Bendesky et al.: "Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis." in: Cancer research, Vol. 71, Issue 1, pp. 245-54, 2011 (PubMed).
Kida, Asahina, Teraoka et al.: "Twist relates to tubular epithelial-mesenchymal transition and interstitial fibrogenesis in the obstructed kidney." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 55, Issue 7, pp. 661-73, 2007 (PubMed).
Gitelman: "Twist protein in mouse embryogenesis." in: Developmental biology, Vol. 189, Issue 2, pp. 205-14, 1997 (PubMed).