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Browse our CD13 Proteins (ANPEP)

Full name:
Alanyl (Membrane) Aminopeptidase Proteins (ANPEP)
On www.antibodies-online.com are 13 Alanyl (Membrane) Aminopeptidase (ANPEP) Proteins from 6 different suppliers available. Additionally we are shipping CD13 Antibodies (563) and CD13 Kits (22) and many more products for this protein. A total of 611 CD13 products are currently listed.
Synonyms:
AP-M, AP-N, APDE, Apm, APN, Cd13, GP150, KZP, Lap1, p150, PEPN, rAPN, SC8E4A.13
list all proteins Gene Name GeneID UniProt
ANPEP 290 P15144
ANPEP 16790 P97449
Rat ANPEP ANPEP 81641 P15684

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CD13 Proteins (ANPEP) by Origin

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Top referenced CD13 Proteins

  1. Human CD13 Protein expressed in Human Cells - ABIN3216379 : Yeager, Ashmun, Williams, Cardellichio, Shapiro, Look, Holmes: Human aminopeptidase N is a receptor for human coronavirus 229E. in Nature 1992 (PubMed)
    Show all 6 references for ABIN3216379

  2. Mouse (Murine) CD13 Protein expressed in Human Cells - ABIN2007127 : Bhagwat, Petrovic, Okamoto, Shapiro: The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathways in endothelial morphogenesis. in Blood 2003 (PubMed)
    Show all 5 references for ABIN2007127

More Proteins for CD13 Interaction Partners

Human Alanyl (Membrane) Aminopeptidase (ANPEP) interaction partners

  1. CD13 expression is associated with hepatoblastoma invasiveness and could be a novel prognostic marker for hepatoblastoma.

  2. Data indicate that fluorogenic substrates can be successfully used to identify aminopeptidase N and to measure their activity in cell lysates.

  3. Data show that CD13 anntigen and receptor tyrosine kinase-like orphan receptor 2 (ROR2 (show ROR2 Proteins)) identify a cardiac lineage precursor pool that is capable of successful engraftment into the porcine heart.

  4. The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP (show IL1RN Proteins) were detected in the jejunal mucosa.

  5. 14-3-3epsilon might directly bind to CD13, which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis.

  6. Alanyl aminopeptidase expression is confined to mature zymogenic chief cells and its expression is lost en route to metaplasia.

  7. Aminopeptidase N activity in tissue and plasma from colorectal cancer patients is an independent prognostic factor of 5-year survival.

  8. Expression of APN/CD13 is a potential unfavorable factor to predict the efficacy and prognosis of post-operative chemotherapy in NSCLC patients, especially in lung adenocarcinoma patients.

  9. We identified a unique HCC line, Li-7, which not only shows heterogeneity for a CD13(+) CSC hierarchy, but also undergoes a "population change" upon CSC differentiation

  10. This study permitted the identification of the novel human LAP1C (show TOR1AIP1 Proteins) isoform and partially unraveled the molecular basis of LAP1 regulation.

Mouse (Murine) Alanyl (Membrane) Aminopeptidase (ANPEP) interaction partners

  1. 14-3-3epsilon might directly bind to CD13, which transmits its signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis.

  2. Alanyl aminopeptidase expression is confined to mature zymogenic chief cells and its expression is lost en route to metaplasia.

  3. CD13 negatively regulates TLR4 (show TLR4 Proteins) signaling, thereby balancing the innate response by maintaining the inflammatory equilibrium critical to innate immune regulation.

  4. The impact of loss of CD13 on a model of ischemic skeletal muscle injury, was investigated.

  5. Molecular mechanisms regulating CD13-mediated adhesion.

  6. CD13 is essential for proper trafficking of the inflammatory cells necessary to prime and sustain the reparative response, thus promoting optimal post-infarction healing.

  7. Tyrosine phosphorylation of CD13 regulates inflammatory cell-cell adhesion and monocyte trafficking.

  8. This indicates that Anpep plays a critical role in the proteolytic remodelling of mammary tissue during adult mammary development.

  9. the presence of digestive protein complexes in the intestinal brush-border containing the peptidases APN and ACE2 (show ACE2 Proteins) and the neutral amino acid transporter B0AT1 (show SLC6A19 Proteins)

  10. cooperation in APN expression by both cancer cells and nonmalignant stromal cells within the tumor microenvironment promotes angiogenesis, tumor growth, and metastasis

Cow (Bovine) Alanyl (Membrane) Aminopeptidase (ANPEP) interaction partners

  1. APN activity is not responsible for betulinic acid-inhibited growth factor-induced angiogenesis in endothelial cells

Pig (Porcine) Alanyl (Membrane) Aminopeptidase (ANPEP) interaction partners

  1. The C-terminal domain of the S1 domain of porcine epidemic diarrhea virus is bound to swine pAPN.

  2. Data indicate that fluorogenic substrates can be successfully used to identify aminopeptidase N and to measure their activity in cell lysates.

  3. SPC (show SFTPC Proteins) subdomain of APN plays a key role in cell entry of PEDV and its expression permits PEDV growth

  4. Porcine epidemic diarrhea virus recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid.

  5. These data demonstrate that pAPN, the cellular receptor for porcine epidemic diarrhea virus, mediates polarized virus infection.

  6. It was concluded that the difference in F4 binding to ANPEP is due to modifications in its carbohydrate moieties.

  7. The region aa 673-722 of the C subunit of porcine aminopeptidase N is indicated to play a key role in swine transmissible gastroenteritis virus binding.

  8. The binding ability of four truncated porcine aminopeptidase N proteins to transmissible gastroenteritis virus (TGEV), a porcine coronavirus, was analyzed by ELISA and immunoblotting.

  9. results demonstrate that aminopeptidase N reduces basolateral Na(+)-K(+)-ATPase (show ATP1A1 Proteins) levels via ANG (show ANG Proteins) IV/AGTRIV signaling. This novel pathway may be important in renal adaptation to high salt

CD13 (ANPEP) Protein Profile

Protein Summary

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.

Alternative names and synonyms associated with CD13 (ANPEP)

  • aminopeptidase N (Apn2)
  • aminopeptidase N (Apn1)
  • aminopeptidase N (SCO2643)
  • aminopeptidase N (pepN)
  • aminopeptidase N (Shewana3_0897)
  • aminopeptidase N (Alvin_1024)
  • aminopeptidase N (Ndas_3413)
  • aminopeptidase N (Arch_0473)
  • aminopeptidase N (Arch_0872)
  • aminopeptidase N (Saut_1544)
  • aminopeptidase N (Fbal_1877)
  • aminopeptidase n (ML5_3424)
  • aminopeptidase N (Despr_1988)
  • aminopeptidase N (Mesop_5365)
  • alanyl (membrane) aminopeptidase (ANPEP)
  • alanyl (membrane) aminopeptidase (Anpep)
  • AP-M protein
  • AP-N protein
  • APDE protein
  • Apm protein
  • APN protein
  • Cd13 protein
  • GP150 protein
  • KZP protein
  • Lap1 protein
  • p150 protein
  • PEPN protein
  • rAPN protein
  • SC8E4A.13 protein

Protein level used designations for ANPEP

aminopeptidase N , aminopeptidase n , AP-M , AP-N , alanyl aminopeptidase , aminopeptidase M , hAPN , microsomal aminopeptidase , myeloid plasma membrane glycoprotein CD13 , aminopeptidase N/CD13 , membrane protein p161 , bAPN , alanyl (membrane) aminopeptidase (aminopeptidase N, aminopeptidase M, microsomal aminopeptidase, CD13, p150) , cluster of differentiation antigen 13 (CD13) , kidney Zn peptidase , kidney aminopeptidase M , leucine arylaminopeptidase 1 , membrane alanine aminopeptidase , fAPN , cAPN , membrane alanine aminiopeptidase , gp130 , pAPN , rbAPN , aminopeptidase Ey

GENE ID SPECIES
692370 Bombyx mori
692563 Bombyx mori
1098077 Streptomyces coelicolor A3(2)
3281350 Neisseria gonorrhoeae FA 1090
4212453 Alcanivorax borkumensis SK2
4477108 Shewanella sp. ANA-3
7114632 Methylobacterium extorquens CM4
8786367 Allochromatium vinosum DSM 180
9247280 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9261042 Arcanobacterium haemolyticum DSM 20595
9261454 Arcanobacterium haemolyticum DSM 20595
9759089 Sulfurimonas autotrophica DSM 16294
9770648 Ferrimonas balearica DSM 9799
10058948 Micromonospora sp. L5
10174716 Desulfobulbus propionicus DSM 2032
10829228 Mesorhizobium opportunistum WSM2075
290 Homo sapiens
16790 Mus musculus
404191 Bos taurus
100050397 Equus caballus
81641 Rattus norvegicus
493785 Felis catus
403913 Canis lupus familiaris
397520 Sus scrofa
100009167 Oryctolagus cuniculus
395667 Gallus gallus
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