Hect Domain and RLD 5 (HERC5) (N-Term) Peptide
HERC5
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all HERC5 products
- HERC5 (Hect Domain and RLD 5 (HERC5))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-HERC5 antibody (Catalog #: ARP43212_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- HERC5 (Hect Domain and RLD 5 (HERC5))
- Synonyms
- HERC5 Peptide, CEB1 Peptide, CEBP1 Peptide, HECT and RLD domain containing E3 ubiquitin protein ligase 5 Peptide, hect domain and RLD 5 Peptide, HERC5 Peptide
- Background
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HERC5 is a probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.
Alias Symbols: CEB1, CEBP1
Protein Interaction Partner: CCNA2,CCNB1,CCND1,CCNE1,CCNA2,CCNB1,CCND1,CCNE1,CDKN1A,ERCC2,NME2,PITX2,STK38
Protein Size: 1024 - Molecular Weight
- 117 kDa
- Gene ID
- 51191
- NCBI Accession
- NM_016323, NP_057407
- UniProt
- Q9UII4
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