Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP) (N-Term) Peptide
ITGB3BP
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all ITGB3BP products
- ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-ITGB3BP antibody (Catalog #: ARP54999_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- ITGB3BP (Integrin beta 3 Binding Protein (Beta3-Endonexin) (ITGB3BP))
- Synonyms
- CENP-R Peptide, CENPR Peptide, HSU37139 Peptide, NRIF3 Peptide, TAP20 Peptide, 4930471O16Rik Peptide, AU022583 Peptide, integrin subunit beta 3 binding protein Peptide, integrin beta 3 binding protein (beta3-endonexin) Peptide, ITGB3BP Peptide, Itgb3bp Peptide
- Background
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ITGB3BP is a transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. ITGB3BP acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. It induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. ITGB3BP may also act as an inhibitor of cyclin A-associated kinase. ITGB3BP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Alias Symbols: CENP-R, CENPR, HSU37139, NRIF3, TAP20
Protein Interaction Partner: MTA1,ARFIP2,CCNA2,COL4A3BP,DDX24,ESR1,ITGB3,ITGB3BP,ITGB5,MTA1,NFKB1,RECQL5,RXRA,ARFIP2,CCNA2,COL4A3BP,DDX24,ITGB3,ITGB3BP,ITGB5,NFKB1,RECQL5,RELA,RXRA,RXRG,THRA
Protein Size: 177 - Molecular Weight
- 20 kDa
- Gene ID
- 23421
- NCBI Accession
- NM_014288, NP_055103
- UniProt
- Q13352
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