Suppressor of Cytokine Signaling 7 (SOCS7) (N-Term) Peptide
SOCS7
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all SOCS7 products
- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
- Protein Region
- N-Term
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Characteristics
- This is a synthetic peptide designed for use in combination with anti-SOCS7 antibody (Catalog #: ARP53700_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Application Notes
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- SOCS7 (Suppressor of Cytokine Signaling 7 (SOCS7))
- Synonyms
- NAP4 Peptide, NCKAP4 Peptide, SOCS4 Peptide, SOCS6 Peptide, 2310063P06Rik Peptide, C85125 Peptide, Nap4 Peptide, GB13951 Peptide, zgc:175115 Peptide, SOCS7 Peptide, socs7 Peptide, suppressor of cytokine signaling 7 Peptide, suppressor of cytokine signaling Peptide, SOCS7 Peptide, Socs7 Peptide, LOC413772 Peptide, socs7 Peptide
- Background
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SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: NAP4, NCKAP4
Protein Interaction Partner: EGFR,GRB2,IRS2,IRS4,NCK1,PIK3R1,PIK3R2,PLCG1,SORBS3,TUBA1A,TUBB2C,NCK1
Protein Size: 581 - Molecular Weight
- 64 kDa
- Gene ID
- 30837
- NCBI Accession
- NM_014598, NP_055413
- UniProt
- O14512
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