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IKKalpha-dependent phosphorylation of S376 stimulated whereas IKKalpha-independent phosphorylation of S484 inhibited RORgammat function in Th17 differentiation.
Akt2 (show AKT2 ELISA Kits), Erk2 (show MAPK1 ELISA Kits), and IKK1/2 phosphorylate Bcl3 (show BCL3 ELISA Kits), converting Bcl3 (show BCL3 ELISA Kits) into a transcriptional coregulator by facilitating its recruitment to DNA.
IKKalpha promotes migration through dynamic interactions with the EGF (show EGF ELISA Kits) promoter depending on the redox state within cells.
the dual regulation of STAT1 (show STAT1 ELISA Kits) by IKKalpha in antiviral signaling suggests a role for IKKalpha in the fine-tuning of antiviral signaling in response to non-self RNA.
In epithelial ovarian cancer cells, miR (show MLXIP ELISA Kits)-23a enhances the expression of IKKalpha. The proliferation, migration, and invasion of EOC cells are increased by IKKalpha.
TLR signaling led to lower expression of LRRC14 (show LRRC14 ELISA Kits).
IKKalpha is an important determinant of poor outcome in patients with ER-positive invasive ductal breast cancer and thus may represent a potential therapeutic target
The molecular mechanisms involved in IKKalpha-related tumors. [review]
this study shows that miR (show MLXIP ELISA Kits)-23a regulated IL-17 (show IL17A ELISA Kits)-mediated proinflammatory mediators expression in rheumatoid arthritis by directly targeting IKKalpha
W346 effectively inhibited tumor necrosis factor (TNF-a (show TNF ELISA Kits))-induced NF-kappaB (show NFKB1 ELISA Kits) activation by suppressing IKK phosphorylation, inhibiting IkB (show NFKBIB ELISA Kits)-a degradation, and restraining the accumulation of NF-kappaB (show NFKB1 ELISA Kits) subunit p65 (show GORASP1 ELISA Kits) nuclear translocation. W346 also affected NF-kappaB (show NFKB1 ELISA Kits)-regulated downstream products involved in cycle arrest and apoptosis.
IKKalpha as a central mediator sensing both cytokine and microbial stimulation to suppress endoplasmic reticulum stress, thereby assuring antiinflammatory function during acute intestinal inflammation.
The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB (show NFKB1 ELISA Kits) by phosphorylating the regulatory molecule TAX1BP1 (show TAX1BP1 ELISA Kits).
Data indicate that the inflammation and proliferation-related functions of I kappa B kinase (IKKbeta (show IKBKB ELISA Kits)) can be uncoupled by quinoxaline urea analog 13-197.
Hematopoietic IKKalpha deficiency in mouse suppresses Akt (show AKT1 ELISA Kits) signaling, compromising monocyte/macrophage survival and this decreases early atherosclerosis.
Anatomy of a negative feedback loop: the case of IkappaBalpha (show NFKBIA ELISA Kits).
Epithelial-intrinsic IKK-alpha expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.
IKKalpha mediated the repair of the kidney via infiltrated regulatory T (Treg) cells, which can produce anti-inflammatory cytokine IL10 (show IL10 ELISA Kits)
phosphorylation of DBC1 (show DBC1 ELISA Kits) at its C terminus by IKKalpha facilitates its interaction with RelB (show RELB ELISA Kits) and IKKalpha, indicating that DBC1 (show DBC1 ELISA Kits)-mediated suppression of alternative NF-kappaB (show NFKB1 ELISA Kits) is regulated by IKKalpha.
IKKalpha controls the inflammasome at the level of the adaptor molecule ASC (show STS ELISA Kits), which interacts with IKKalpha in the nucleus of resting macrophages in an IKKalpha kinase-dependent manner.
These findings reveal a molecular mechanism regulating migration and invasion of epithelial cells and establish a key direct link between IKKbeta (show IKBKB ELISA Kits) and cell motility controlled by Rap (show LRPAP1 ELISA Kits)-integrin signaling.
poky/chuk/ikk1 is required for differentiation of the zebrafish embryonic epidermis
Ikk1 negatively regulates NF-kappaB (show NFKB1 ELISA Kits) by sequestering NEMO (show IKBKG ELISA Kits) from active IKK complexes, indicating that IKK1 can function as a repressor of NF-kappaB (show NFKB1 ELISA Kits).
This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.
, i kappa-B kinase alpha
, inhibitor of nuclear factor kappa-B kinase subunit alpha
, nuclear factor NF-kappa-B inhibitor kinase alpha
, SPFH domain-containing protein 1
, conserved helix-loop-helix ubiquitous kinase
, I-kappa-B kinase 1
, I-kappa-B kinase-alpha
, IKK-a kinase
, IkB kinase alpha subunit
, Nuclear factor NFkappaB inhibitor kinase alpha
, transcription factor 16
, I kappa B kinase 1
, I-kappa-B kinase alpha
, IKK alpha
, IkappaB kinase alpha
, ikappaB kinase
, IkB kinase-a