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Top referenced anti-Cyclin D1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Human Monoclonal Cyclin D1 Primary Antibody for IHC (p) - ABIN1687223
Kunder, Calzada-Wack, Hölzlwimmer, Müller, Kloss, Howat, Schmidt, Höfler, Warren, Quintanilla-Martinez et al.: A comprehensive antibody panel for immunohistochemical analysis of formalin-fixed, paraffin-embedded hematopoietic neoplasms of mice: analysis of mouse specific and human antibodies cross-reactive ... in Toxicologic pathology 2007
Human Monoclonal Cyclin D1 Primary Antibody for IHC (p), WB - ABIN1686967
Tsai, Morais, Alshalalfa, Tan, Haddad, Hicks, Gupta, Epstein, Netto, Isaacs, Luo, Mehra, Vessella, Karnes, Schaeffer, Davicioni, De Marzo, Lotan: Cyclin D1 Loss Distinguishes Prostatic Small-Cell Carcinoma from Most Prostatic Adenocarcinomas. in Clinical cancer research : an official journal of the American Association for Cancer Research 2015
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.Synonyms: BCL-1 oncogene, BCL1, CCND1, Cyclin-D1, G1/S-specific cyclin-D1, PRAD-1 oncogene, PRAD1