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|Antigen||Glycogen Synthase 1 (Muscle) (GYS1) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-Glycogen Synthase 1 AntibodyTarget Details Glycogen Synthase 1 Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||Synthetic peptide derived from human Glycogen synthase 1(S641), around 630-680aa (phospho S641).|
Target Details Glycogen Synthase 1Product Details anti-Glycogen Synthase 1 Antibody Application Details Handling Images back to top
|Alternative Name||Glycogen synthase 1 (GYS1 Antibody Abstract)|
Glycogen Synthase (GS) is a key enzyme in the regulation of glycogen metabolism. GS catalyzes the incorporation of UDP-glucose incorporation into glycogen. The activity of glycogen synthase is regulated by hormonal stimuli (insulin, catecholamines and glucagons) and non-hormonal stimuli (blood glucose level and exercise). Two main isoforms of mammalian GS are designated as muscle (glycogen synthase 1) and liver (glycogen synthase 2). Most tissues express glycogen synthase 1, whereas glycogen synthase 2 appears to be tissue-specific. The two isoforms have 70 % identical amino acid sequence. Glycogen synthase can be phosphorylated by multiple kinases including glycogen synthase kinase-3 (GSK-3), mitogen-activated protein kinase-related protein kinase (DYRK), and SAPK2b/p38b which leads to its inactivation.
Synonyms: Glycogen synthase 1 phospho S640, Glycogen synthase 1 phospho Ser640, p-Glycogen synthase 1 S640, Glycogen synthase 1 muscle, Glycogen synthase 1, GSY, GYS, GYS1, EC 22.214.171.124, Glycogen synthase1, GYS 1, Starchsynthase muscle, UDP glucose glycogen glucosyltransferase, GYS1_HUMAN, Glycogen [starch] synthase, muscl.
|Research Area||Cancer, Metabolism|
|Pathways||PI3K-Akt Signaling, AMPK Signaling, Cellular Glucan Metabolic Process|
Application DetailsProduct Details anti-Glycogen Synthase 1 Antibody Target Details Glycogen Synthase 1 Handling Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-Glycogen Synthase 1 Antibody Target Details Glycogen Synthase 1 Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
ImagesProduct Details anti-Glycogen Synthase 1 Antibody Target Details Glycogen Synthase 1 Application Details Handling back to top