A synthetic peptide from internal part of rat Huntingtin (Huntington disease protein homolog, Htt, HD protein homolog) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen shares 87% identity with mouse and human sequences.
Huntington's disease (HD) is a neurodegenerative disorder caused by an expandingpolyglutamine repeat in the huntingtin gene. HD is a mid-life onset autosomal dominantneurodegeneative disease that is characterized by psychiatric disorders, dementia, andinvoluntary movements (chorea), leading to death in 10-20 years. The HD gene productis widely expressed in human tissues, with the highest level of expression in the brain.The huntingtin gene product is expressed at similar levels in patients and controls,which suggests that the expansion of the polyglutamine repeat induces a toxic gain offunction perhaps through interactions with other cellular proteins. Using yeast two-hybridsystem, HAP1 (huntingtin associated protein 1) has been identified, that associates withhuntingtin protein. The In vitro data suggest that the association between HAP1 andhuntingtin is enhanced by increasing length of glutamine repeat. Alternate Names: anti-AI256365 antibody, anti-C430023I11Rik antibody, anti-HD antibody, anti-HD proteinantibody, anti-HDH antibody, anti-HTT antibody, anti-HUNTINGTON CHOREA antibody,anti-Huntington disease protein antibody, anti-Huntington's disease protein homologantibody, anti-IT 15 antibody, anti-IT15 antibody, anti-OTTMUSP00000026909 antibody,anti-ZHD antibody. Gene Symbol: HTT