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Browse our PIP5K1A Proteins (PIP5K1A)

Full name:
Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha Proteins (PIP5K1A)
On www.antibodies-online.com are 5 Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) Proteins from 3 different suppliers available. Additionally we are shipping PIP5K1A Antibodies (34) and many more products for this protein. A total of 41 PIP5K1A products are currently listed.
Synonyms:
PIP5K1A, pip5k1b, pip5k1c, Pipk5a, Pipk5b
list all proteins Gene Name GeneID UniProt
Rat PIP5K1A PIP5K1A 365865  
PIP5K1A 18720 P70182
PIP5K1A 8394 Q99755

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PIP5K1A Proteins (PIP5K1A) by Origin

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More Proteins for PIP5K1A Interaction Partners

Mouse (Murine) Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) interaction partners

  1. Data suggest that c-Fos (proto-oncogene protein c-fos; not c-Jun) regulates phospholipid synthesis in cell nucleus; c-Fos localizes to nucleus and modulates genetic transcription through activation of Pip5k1.

  2. optimal PIP5KIgamma (show PIP5K1C Proteins) and PI(4,5)P(2) expression, by osteoclasts, are essential for skeletal homeostasis

  3. Our findings suggest that PI4P5Kalpha plays a complex role in restricting insulin release from pancreatic beta-cells through helping to maintain plasma membrane PIP(2) levels and integrity of the actin cytoskeleton under both basal and stimulatory conditions.

  4. The results suggested that PIP5K1A (show PIP5K1B Proteins) and PIP5K1B (show PIP5K1B Proteins) may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis.

  5. findings indicate that synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) by the three phosphatidylinositol 4-phosphate 5-kinase (show PIP4K2C Proteins) (PIP5K (show PIKFYVE Proteins)) isoforms Ialpha, Ibeta and Igamma is controlled by Rho GTPases

  6. that membrane turnover events regulating ENaC (show SCNN1A Proteins) surface expression and activity in oocytes and CCD (show RUNX2 Proteins) cells can be regulated by PI5KIalpha.

  7. after stimulation of a G protein-coupled receptor (show GPR34 Proteins), IP(3) is completely derived from a rapidly synthesized discrete pool of PIP(2) synthesized by PIP5KIalpha (show PIP5K1B Proteins) and PIP5KIbeta (show PIP5K1B Proteins)

  8. PIP5K (show PIKFYVE Proteins)-Ialpha may play an important role in both the proximal and distal steps of signaling cascade for insulin (show INS Proteins) secretion in beta-cells.

Human Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) interaction partners

  1. PIP5K1A modulates ribosomal RNA gene silencing through its interaction with histone H3 (show HIST3H3 Proteins) lysine 9 trimethylation and heterochromatin protein HP1-alpha (show CBX5 Proteins).

  2. PIP5K1A is modified by polySUMO-2 only during apoptosis.

  3. CD28 (show CD28 Proteins) regulates phosphatidylinositol 4,5-biphosphate turnover by recruiting and activating phosphatidylinositol 4-phosphate 5-kinases alpha in human primary CD4 (show CD4 Proteins)(+) T lymphocytes.

  4. Results define the role of PIPKI-alpha in cell migration and describes a new mechanism for the spatial regulation of Rac1 activity that is critical for cell migration.

  5. Localized production of Phosphatidylinositol 4,5-bisphosphate by PIP5K1A is required for invadopodia formation by breast cancer cells.

  6. Membrane ruffling requires coordination between this enzyme and Rac (show AKT1 Proteins) signaling.

  7. in addition to its effects upon Rac activity, Ajuba can also influence cell migration through regulation of PI(4,5)P2 synthesis through direct activation of PIPKIalpha enzyme activity

  8. identified apoptotic stimuli that initiate a signaling pathway during cell death that leads to caspase (show CASP3 Proteins)-independent downregulation of PIP5Kalpha.

  9. Type I phosphatidylinositol-4-phosphate-5-kinase (PI5KI) alpha and gamma isoforms were identified as the enzymes responsible for PIP2 synthesis in natural killer cells.

  10. beta-arrestins direct the localization of PIP5K Ialpha and PIP(2) production to agonist-activated 7TMRs, thereby regulating receptor internalization

PIP5K1A Protein Profile

Protein Summary

Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.

Alternative names and synonyms associated with PIP5K1A

  • phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (Pip5k1a)
  • phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (pip5k1a)
  • phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (PIP5K1A)
  • phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha (Pip5k1a)
  • PIP5K1A protein
  • pip5k1b protein
  • pip5k1c protein
  • Pipk5a protein
  • Pipk5b protein

Protein level used designations for PIP5K1A

phosphatidylinositol-4-phosphate 5-kinase type-1 alpha , phosphatidylinositol-4-phosphate 5-kinase, type 1 beta , phosphatidylinositol-4-phosphate 5-kinase, type I, alpha , phosphatidylinositol-4-phosphate 5-kinase, type I, beta , 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase , 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase , PI4P5K-I[a] , PI4P5KIbeta , PIP5K1-alpha , PIP5KIalpha , phosphatidylinositol 4-phosphate 5-kinase type I alpha , phosphatidylinositol 4-phosphate 5-kinase type I beta , phosphatidylinositol 4-phosphate 5-kinase type-1 alpha , phosphatidylinositol-4-phosphate 5-kinase type I alpha , phosphatidylinositol-4-phosphate 5-kinase type I beta , ptdIns(4)P-5-kinase 1 alpha , 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha , 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha

GENE ID SPECIES
365865 Rattus norvegicus
399203 Xenopus laevis
429983 Gallus gallus
448746 Xenopus (Silurana) tropicalis
457288 Pan troglodytes
475846 Canis lupus familiaris
710007 Macaca mulatta
100017950 Monodelphis domestica
100059655 Equus caballus
100125224 Bos taurus
100137415 Papio anubis
18720 Mus musculus
8394 Homo sapiens
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