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anti-Human PITRM1 Antibodies:
anti-Mouse (Murine) PITRM1 Antibodies:
anti-Rat (Rattus) PITRM1 Antibodies:
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BCL2 (show BCL2 Antibodies) expression in mesennchymal lung cancer cells was induced by ERK1 (show MAPK3 Antibodies) activity through the upregulation of the MEK1 (show MAP2K1 Antibodies)/ERK1 (show MAPK3 Antibodies) scaffold protein (show HOMER1 Antibodies) MEK partner-1 (show MAPKSP1 Antibodies). Interfering with the MEK1 (show MAP2K1 Antibodies)/MP1/ERK1 (show MAPK3 Antibodies) axis using a MEK1 (show MAP2K1 Antibodies) inhibitor or MP1 depletion repressed BCL2 (show BCL2 Antibodies) expression and sensitized MLCCs to chemoradiotherapy.
The authors identified two siblings carrying a homozygous PITRM1 missense mutation (c.548G>A, p.Arg183Gln) associated with an autosomal recessive, slowly progressive syndrome characterised by mental retardation, spinocerebellar ataxia, cognitive decline and psychosis.
The present study was aimed at investigating whether the miR (show MLXIP Antibodies)-29c binding site single nucleotide polymorphisms within the 3'-UTRs of LAMTOR3 (show MAPKSP1 Antibodies) gene affected the gastric cancer risk.
we demonstrate that the MAPK (show MAPK1 Antibodies) scaffold protein (show HOMER1 Antibodies) MEK partner 1 (MP1 (show MAPKSP1 Antibodies)) is important for gastrin (show GAST Antibodies)-induced phosphorylation of ERK1 (show MAPK3 Antibodies) and ERK2 (show MAPK1 Antibodies) and that MP1 promotes gastrin (show GAST Antibodies)-induced proliferation of AGS (show JAG1 Antibodies)-GR cells
identified polymorphisms in LAMTOR2 (show LAMTOR2 Antibodies) and LAMTOR3 (show MAPKSP1 Antibodies) do not seem to play a relevant role in breast cancer
Data show that the hPreP presequence only targets GFP to the matrix of mammalian and yeast mitochondria.
This study demonstrated decreased proteolytic activity of the mitochondrial amyloid-beta degrading enzyme, PreP peptidasome, in Alzheimer's disease brain mitochondria.
A complex encoded by the MAPKSP1 (show MAPKSP1 Antibodies), ROBLD3 (show LAMTOR2 Antibodies), and c11orf59 (show LAMTOR1 Antibodies) genes interacts with the Rag GTPases, recruits them to lysosomes, and is essential for mTORC1 activation
our data suggest that genetic variation in the hPreP gene PITRM1 may potentially contribute to mitochondrial dysfunctions
The substrate specificity of the mitochondrial metallopeptidase proteinase 1 (MP1) was investigated and its mitochondrial targeting signal identified.
results suggest that pitrilysin regulates islet amyloid polypeptide (show IAPP Antibodies) in beta cells and suggest the presence of an intramitochondrial pool of islet amyloid polypeptide (show IAPP Antibodies) involved in beta-cell apoptosis.
Pitrm1 is expressed in Pax3 (show PAX3 Antibodies)-expressing myoblast progenitors in the limb, the dermomyotome, and developing muscles of the face and torso.
ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference.
MAPK scaffold protein 1
, MEK binding partner 1
, late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
, mitogen-activated protein kinase kinase 1 interacting protein 1
, mitogen-activated protein kinase scaffold protein 1
, ragulator complex protein LAMTOR3
, PreP peptidasome
, metalloprotease 1 (pitrilysin family)
, pitrilysin metalloproteinase 1
, presequence protease, mitochondrial
, nuclear transplantation upregulated protein 1
, pitrilysin metalloprotease 1
, pitrilysin metallepetidase 1
, Pitrilysin metalloproteinase 1