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MiR-9 regulates GR signaling and steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity.
activation of the B56delta-containing heterotrimeric form of PP2A is responsible for enhanced dephosphorylation of Ser40 of tyrosine hydroylase in response to stimulation of PKC
Mice lacking phosphatase PP2A (show PPP2R2B Proteins) subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 (show CDK5 Proteins) and GSK3beta.
A comparative expression study of Ppp2r5d and Mea1 (show MEA1 Proteins) in spermatogenesis.
Mutations in PPP2R5D are genetic cause of intellectual disability.
Mutations in the PP2A (show PPP2R4 Proteins) regulatory subunit B family genes PPP2R5B (show PPP2R5B Proteins), PPP2R5C (show PPP2CA Proteins) and PPP2R5D cause human overgrowth
PP2A (show PPP2R4 Proteins)-B56delta is the single most significant contributor, of the PP2A (show PPP2R4 Proteins) holoenzyme subunits, to BubR1 (show BUB1B Proteins) and Bub1 (show BUB1 Proteins) kinetochore localization.
Protein kinase A mediated activation of protein phosphatase 2A is enabled by PPP2R5D phosphorylation, which modulates the affinity of the protein phosphatase 2A holoenzyme to its physiological substrates.
Data show that the protein phosphatase 2A subunit B56delta specifically interacts with HAND1 (show HAND1 Proteins) and -2, but not other basic helix-loop-helix proteins.
Gonadotropin-releasing hormone (GnRH) affects the membrane protein phosphatase 2A-associated apoptosis and the enzyme activity in ovarian cancer cells.
PP2A (show PPP2R4 Proteins) ABalphaC and ABdeltaC holoenzymes function as positive regulators of Raf1 (show RAF1 Proteins)-MEK1 (show MAP2K1 Proteins)/2-ERK1/2 signaling by targeting Raf1 (show RAF1 Proteins)
PP2A:B56delta as a key upstream regulator of Cdk1 (show CDK1 Proteins) activity upon exit from mitosis
these data indicate that the B subunits alpha and delta are essential for the interaction of PP2A (show PPP2R4 Proteins) with CaMKIV (show CAMK4 Proteins).
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
, protein phosphatase 2, regulatory subunit B', delta isoform
, delta isoform of regulatory subunit B56, protein phosphatase 2A
, protein phosphatase 2, regulatory subunit B', delta
, delta isoform of regulatory subunit B56, protein phosphatase 2A-like
, serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform-like
, testis expressed gene 271
, PP2A B subunit isoform B'-delta
, PP2A B subunit isoform B56-delta
, PP2A B subunit isoform PR61-delta
, PP2A B subunit isoform R5-delta
, PP2A, B subunit, B' delta isoform
, PP2A, B subunit, B56 delta isoform
, PP2A, B subunit, PR61 delta isoform
, PP2A, B subunit, R5 delta isoform
, Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform
, protein phosphatase 2, regulatory subunit B (B56), delta isoform
, PP2A B subunit isoform B'-gamma
, PP2A, B subunit, B'-gamma
, protein phosphatase PP2A0 B' subunit gamma isoform