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12(S)-HETrE, a 12-lipoxygenase oxylipin of dihomo-gamma-linolenic acid, inhibits thrombosis via Galphas (show GNAS Proteins) signaling in platelets.
Results identified a novel ALOX12 locus (indicated by two SNPs in perfect linkage disequilibrium: rs1042357 and rs10852889) that moderated the association between PTSD and reduced thickness of the right prefrontal cortex.
The regulation of important oxylipin metabolic genes in peripheral blood mononuclear cells varied with the extent of change in arachidonic acid concentrations in the case of PTGS1 (show PTGS1 Proteins) and ALOX12 regulation.
ITGB4 (show ITGB4 Proteins) stimulation leads to recruitment of 12-LOX from the cytosol to the membrane.
In the highest tertile with ALOX12.
the amount of LPL (show LCP1 Proteins) expressed in muscle and heart governed both the binding of chylomicron particles and the assimilation of chylomicron lipids in the tissue.
Results suggest that Alox12 protein polymorphisms did not discriminate for psoriasis severity.
Results indicate that secreted phospholipase A2 IIA (sPLA (show YWHAZ Proteins)2-IIA) as an en (show PLA2G2A Proteins)zyme working in concert with platelet microparticles (MPs) 12-lipoxygenase (12-LO) to promote internalization.
IGF-1 (show IGF1 Proteins) reduces lipid oxidation and foam cell formation via downregulation of 12/15-LOX (show ALOX15 Proteins) to prevent atherosclerosis.
The costaining of pancreatic polypeptide (show PPY Proteins) and vimentin (show VIM Proteins) suggests that 12-LO participates in the process leading to beta-cell dedifferentiation in the islet.
the amount of LPL (show LPL Proteins) expressed in muscle and heart governed both the binding of chylomicron particles and the assimilation of chylomicron lipids in the tissue.
Data show that the coordinated action of phospholipase A2 (show YWHAZ Proteins) IIA (sPLA2-IIA (show PLA2G2A Proteins)) and 12-lipoxygenase (12-LO (show ALOX15 Proteins)) promotes inflammatory arthritis.
These results suggest that cardiac 12/15-LOX (show ALOX15 Proteins)-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy and that inhibition of 12/15-LOX (show ALOX15 Proteins) could be a novel treatment for this condition.
EET-heme oxygenase-1 (show HMOX1 Proteins) crosstalk as an important cytoprotective mechanism in the amelioration of vascular and adipocyte dysfunction resulting from diet-induced obesity.
Findings suggest 12/15-LOX (show ALOX15 Proteins) expressed in non-epithelial cells such as macrophages and fibroblasts leads to bronchial epithelial injury.
Data indicate that intravenous injection of B16F10 melanoma cells caused lung nodule formation, which was markedly attenuated in 12/15-Lipoxygenase (12/15-LOX (show ALOX15 Proteins)) null mice.
Following middle cerebral artery occlusion to induce stroke, immunohistochemistry shows both Sema3A (show SEMA3A Proteins) and 12/15-LOX (show ALOX15 Proteins) are increased in the cortex up to 2 wk.
ALOX12 may have a role in growth of breast cancer, and its inhibition may be a strategy for inhibiting tumor growth
The crystal structure of a mammalian 12-lipoxygenase reveals a plausible substrate access channel for oxygen.
12/15-Lipoxygenase activity increases the degradation of macrophage ATP-binding cassette transporter G1.
EPR (show EREG Proteins) spectroscopy and electrospray mass spectroscopy reveal distinctive features of the iron site in leukocyte arachidonate 12-lipoxygenase.
Oxygenase and 14,15-leukotriene A4 synthase activity.
, arachidonate 12-lipoxygenase, 12S-type
, platelet 12-LOX
, platelet-type 12-lipoxygenase
, platelet-type lipoxygenase 12
, arachidonate 15-lipoxygenase