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all of the reported mutations were found to have occurred in a highly conserved region in the NACHT domain coding sequence in NLRP12 exon 3, suggesting that a screening strategy for Familial cold autoinflammatory syndrome should focus on this area of the gene
The novel findings reveal the critical role of NLRP12-IL-17A (show IL17A Proteins)-CXCL1 (show CXCL1 Proteins) axis in host defense by modulating neutrophil recruitment against Klebsiella pneumoniae.
This process involved the upregulation of NLRP12.
NLRX1, NLRP12 and NLRC3 negatively modulate the host immune response following virus exposure. (Review)
Variants of NLRP12 were associated with common variable immunodeficiency.
NLRP12/NLRP3 (show NLRP3 Proteins)-dependent activation of caspase-1 (show CASP1 Proteins) is likely to be a key event in mediating systemic production of IL-1beta (show IL1B Proteins) and hypersensitivity to secondary bacterial infection during malaria.
The genetics, expression and roles of NLRP12 in inflammatory signaling, host defense, and carcinogenes (show GUSB Proteins)is are reviewed. Review.
This study suggested that NLRP12 mutations might account for a small fraction of common variable immunodeficiency patients with severe auto-inflammatory complications.
We will focus on NLRP6 and NLRP12.
Letter: NLRP12 mutations associated with familial cold autoinflammatory syndrome 2 in Italian patients.
this study shows that NLRP12 is essential for survival after radiation and thermal combined injury by regulating myelopoiesis and immune reconstitution
our findings suggest that NLRP12 plays an important role in negatively regulating the early inflammatory responses against B. abortus.
this study reveals a feed-forward loop in which NLRP12 promotes specific commensals that can reverse gut (show GUSB Proteins) inflammation, while cytokine blockade during NLRP12 deficiency can reverse dysbiosis
Ambient fine particulate matter-induced myocarditis is mediated by EGFR (show EGFR Proteins)/Akt (show AKT1 Proteins) signaling and overexpression of NLRP3 (show NLRP3 Proteins) and NLRP12.
Nlrp12 deficiency caused increased neutrophil migration towards the chemokine (show CCL1 Proteins) CXCL1 (show CXCL1 Proteins) and the neutrophil parasite Leishmania major, revealing NLRP12 as a negative regulator of directed neutrophil migration under these conditions.
modulation of NLRP12 levels controls alternative NF-kappaB (show NFKB1 Proteins) signaling in OC precursors, altering bone homeostasis and osteolytic responses
The absence of Nlrp12 results in an increased inflammatory response
NLRP12 is an intrinsic negative regulator of T-cell-mediated immunity via altered NF-kappaB (show NFKB1 Proteins) regulation and IL-4 (show IL4 Proteins) production as key mediators of NLRP12-associated disease.
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants.
NACHT, leucine rich repeat and PYD containing 12
, NLR family, pyrin domain containing 12
, PYRIN-containing APAF1-like protein 7
, NACHT, LRR and PYD domains-containing protein 12
, NLR family, pyrin domain containing 12, isoform 2
, monarch 1
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12
, regulated by nitric oxide
, NACHT, LRR and PYD containing protein 12