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dOgg1 and RpS3 in mitochondria increase cell survival after exposure to the nitric oxide donor SNAP
Short 5'UTR (show UTS2R ELISA Kits) mRNAs are enriched with TISU (translation initiator of short 5'UTR (show UTS2R ELISA Kits)), a 12-nucleotide element directing efficient scanning-independent translation. This study demonstrate that TISU is particularly dependent on eukaryotic initiation factor (show EIF4G1 ELISA Kits) 1A (eIF1A (show EIF1AX ELISA Kits)) which interacts with both RPS3 and RPS10e.
Data show that ribosomal protein S3 (RPS3) knockdown decreased mitochondrial calcium uptake 1 (show MICU1 ELISA Kits) protein (MICU1 (show MICU1 ELISA Kits)) expression.
a novel cell fate determination mechanism to ensure cells undergo programed cell death through interfering with RPS3/NF-kappaB (show NFKB1 ELISA Kits)-conferred anti-apoptotic transcription by the fragment from partial p65 (show GORASP1 ELISA Kits) cleavage by activated Caspase-3 (show CASP3 ELISA Kits)
Increased RPS3 expression is associated with osteosarcoma invasion.
RPS3, a component of basic translation machinery operates at initiation and most probably elongation of protein synthesis, is also implicated in various events of the cell life as an extraribosomal player. [Review]
IkappaBalpha (show NFKBIA ELISA Kits) sequesters not only p65 (show GORASP1 ELISA Kits) but also RPS3 in the cytoplasm.
These findings suggest that the secreted rpS3 protein is an indicator of malignant tumors.
rpS3 accumulates in the mitochondria to repair damaged DNA due to the decreased interaction between rpS3 and HSP90 (show HSP90 ELISA Kits) in the cytosol.
rpS3 acts as a microtubule associated protein and regulates spindle dynamics during mitosis.
A novel radioresistance mechanism through functional orchestration of rpS3, TRAF2 (show TRAF2 ELISA Kits), and NF-kappaB (show NFKB1 ELISA Kits) in non-small cell lung cancer cells, is reported.
The RPS3 gene silencing ameliorates experimental asthma, probably by disrupting NF-kappaB (show NFKB1 ELISA Kits) activity. RPS3 could be a novel therapeutic target for allergic airway inflammation.
a novel cell fate determination mechanism to ensure cells undergo programed cell death through interfering with RPS3/NF-kappaB (show NFKB1 ELISA Kits)-conferred anti-apoptotic transcription by the fragment from partial p65 (show NFkBP65 ELISA Kits) cleavage by activated Caspase-3 (show CASP3 ELISA Kits)
Rps3 knockdown increased the radiation sensitivity of FDC-P1, confirming that the mechanism of action of Lxn (show LXN ELISA Kits) is mediated by Rps3 pathway.
RpS3 is expressed only in activated microglia after lipopolysaccharide treatment; strong rpS3 immunoreactivity is shown in non-pyramidal and non-granule cells.
oxidative stress regulates the phosphorylation status of nonribosomal rpS3 by both activating PKCdelta (show PKCd ELISA Kits) and blocking the PP2A interaction with rpS3
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
40S ribosomal protein S3-A
, ribosomal protein S3
, rps3 gene
, 40S ribosomal protein S3
, IMR-90 ribosomal protein S3