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Human BLK Protein expressed in Baculovirus infected Insect Cells - ABIN2003390
Drebin, Hartzell, Griffin, Campbell, Niederhuber: Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk). in Oncogene 1995
Show all 4 references for ABIN2003390
Human BLK Protein expressed in Escherichia coli (E. coli) - ABIN667955
Dymecki, Niederhuber, Desiderio: Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. in Science (New York, N.Y.) 1990
Show all 2 references for ABIN667955
our study reveals a previously unappreciated role of reduced BLK (show BIK Proteins) expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
BLK (show BIK Proteins) risk alleles confer susceptibility to systemic lupus erythematosus through the dysregulation of a proinflammatory cytokine network.
this study has revealed a previously unappreciated role for Blk (show BIK Proteins) in the development and activation of MZ B cells
BCR-ABL (show ABL1 Proteins) downregulates the Blk (show BIK Proteins) gene (encoding B-lymphoid kinase) through c-Myc (show MYC Proteins) in leukemic stem cells in chronic myeloid leukemia (show BCL11A Proteins)
Data suggest a role of tyrosine kinase (show TYRO3 Proteins) Btk (show BTK Proteins) in the regulation of immune cell unctions and innate inflammatory response.
Analysis of Blk (show BIK Proteins)-deficient mice reveals that Blk (show BIK Proteins) is required for the development of IL-17 (show IL17A Proteins)-producing gammadelta T cell effectors and plays a role in regulating thymus cellularity during ontogeny.
sustained activation of Blk (show BIK Proteins) induces responses normally associated with the pre-BCR (show BCR Proteins).
Blk (show BIK Proteins), being exceptionally highly expressed in the initial segment, is suggested to have a role in the differentiation of this segment of the epididymis.
rs13277113 GA genotype of BLK is more frequent in Systemic Lupus Erythematosus patients and may have a role in low gene expression and increased flares
current meta-analysis suggested that FAM167A-BLK rs2736340 polymorphism is associated with several autoimmune diseases
the SNPs in TNFSF4 and FAM167A-BLK may be involved in asthma and allergic rhinitis gene risk in the Han Chinese cohort.
The systemic lupus erythematosus variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function.
Report a novel BLK gene variant in common variable immunodeficiency-patients that causes suppressed B-cell proliferation and reduced ability of B-cells to elicit antigen-specific CD4 (show CD4 Proteins)(+) T-cell responses.
A major mechanism underlying the BLK association with autoimmune disease involves lowered thresholds for basal B cell receptor signaling, enhanced B cell-T cell interactions, and altered patterns of isotype switching.
our study reveals a previously unappreciated role of reduced BLK expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
Results support previous findings that vaiants in the RHOB and FAM167A-BLK genes may be associated with susceptibility to systemic sclerosis.
These results place Blk upstream of the p190RhoGAP (show GRLF1 Proteins)-RhoA (show RHOA Proteins) pathway in Galpha13 (show GNA13 Proteins)-activated cells, overall representing an opposing signaling module during CXCL12 (show CXCL12 Proteins)-triggered invasion.
Report role of BLK genetic variants in confering risk of systemic lupus erythematosus in Chinese population.
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.
B lymphoid kinase
, tyrosine-protein kinase Blk
, B lymphoid tyrosine kinase
, tyrosine-protein kinase Blk-like
, b lymphocyte kinase
, BLK nonreceptor tyrosine kinase