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our study reveals a previously unappreciated role of reduced BLK (show BIK Proteins) expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
BLK (show BIK Proteins) risk alleles confer susceptibility to systemic lupus erythematosus through the dysregulation of a proinflammatory cytokine network.
this study has revealed a previously unappreciated role for Blk (show BIK Proteins) in the development and activation of MZ B cells
BCR-ABL (show ABL1 Proteins) downregulates the Blk (show BIK Proteins) gene (encoding B-lymphoid kinase) through c-Myc (show MYC Proteins) in leukemic stem cells in chronic myeloid leukemia (show BCL11A Proteins)
Data suggest a role of tyrosine kinase (show TYRO3 Proteins) Btk (show BTK Proteins) in the regulation of immune cell unctions and innate inflammatory response.
Analysis of Blk (show BIK Proteins)-deficient mice reveals that Blk (show BIK Proteins) is required for the development of IL-17 (show IL17A Proteins)-producing gammadelta T cell effectors and plays a role in regulating thymus cellularity during ontogeny.
sustained activation of Blk (show BIK Proteins) induces responses normally associated with the pre-BCR (show BCR Proteins).
Blk (show BIK Proteins), being exceptionally highly expressed in the initial segment, is suggested to have a role in the differentiation of this segment of the epididymis.
This meta-analysis confirms that polymorphisms in the BLK alleles rs13277113 A/G, rs2736340 T/C, and rs2248932 T/C are associated with susceptibility to SLE in Caucasian and Asian populations.
Confirm the association of rs548234/ATG5, rs2736340/BLK and rs10516487/BANK1 with systemic lupus erythematosus in Chinese Han and reinforced our hypothesis of their epistasis effect in regulating B-cell signaling in SLE.
ur study provides evidence that human BLK is a true proto-oncogene (show RAB1A Proteins) capable of inducing tumors, and we demonstrate a novel BLK activity-dependent tumor model suitable for studies of BLK-driven lymphomagenesis and screening of novel BLK inhibitors in vivo.
rs13277113 GA genotype of BLK is more frequent in Systemic Lupus Erythematosus patients and may have a role in low gene expression and increased flares
current meta-analysis suggested that FAM167A-BLK rs2736340 polymorphism is associated with several autoimmune diseases
the SNPs in TNFSF4 and FAM167A-BLK may be involved in asthma and allergic rhinitis gene risk in the Han Chinese cohort.
The systemic lupus erythematosus variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function.
Report a novel BLK gene variant in common variable immunodeficiency-patients that causes suppressed B-cell proliferation and reduced ability of B-cells to elicit antigen-specific CD4 (show CD4 Proteins)(+) T-cell responses.
A major mechanism underlying the BLK association with autoimmune disease involves lowered thresholds for basal B cell receptor signaling, enhanced B cell-T cell interactions, and altered patterns of isotype switching.
our study reveals a previously unappreciated role of reduced BLK expression on extraperitoneal accumulation of B1a cells in mice, as well as the presence of IgG autoantibodies and B1-like cells in humans.
This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.
B lymphoid kinase
, tyrosine-protein kinase Blk
, B lymphoid tyrosine kinase
, tyrosine-protein kinase Blk-like
, b lymphocyte kinase
, BLK nonreceptor tyrosine kinase