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Furthermore, both Ogt (show OGT Proteins) and Oga (show MGEA5 Proteins) were required for the reversion from primed ESD (show ESD Proteins)-EpiSCs to naive rESCs. These findings indicate that O-GlcNAcylation plays an important role in the survival of primed ESD (show ESD Proteins)-EpiSCs and in their reversion to naive rESCs.
the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT (show OGT Proteins)) and O-GlcNAcase (OGA (show MGEA5 Proteins)), interact with the (A)gamma-globin (show HBG1 Proteins) promoter at the -566 GATA repressor (show ZBTB32 Proteins) site
Oga (show MGEA5 Proteins)(+/-) mice resist high-fat diet-induced obesity with ameliorated hepatic steatosis and improved glucose metabolism
plays a critical role in placental vasculogenesis by modulating HIF-1alpha (show HIF1A Proteins) stabilization
E2F1 (show E2F1 Proteins) negatively regulates both Ogt (show OGT Proteins) and Mgea5 (show MGEA5 Proteins) expression in an Rb1 (show RB1 Proteins) protein-dependent manner.
Conditional disruption of the O-GlcNAcase (show MGEA5 Proteins) in mice leads to metabolic deregulation and semi-penetrant perinatal lethality.
This work identifies the first target of miR (show MLXIP Proteins)-539 in the heart and the first miRNA that regulates OGA (show MGEA5 Proteins).
A comprehensive phenotypic analysis of mice deficient in two of the most widely expressed HAT/DESC proteases, TMPRSS11A and HAT, was performed.
The O-GlcNAcase (show MGEA5 Proteins) active site resembles those of glycosidases which carry out the hydrolysis of GlcNAc linkages in a substrate-assisted acid-base manner.
HAT expression may potentially be useful as a marker for clinical grading and assessment of patient prognosis in squamous cell carcinomas
H9N2 viruses with R-S-S-R or R-S-R-R cleavage sites in hemagglutinin (show HA Proteins) are activated by matriptase (show ST14 Proteins) in addition to HAT (show MGEA5 Proteins) and TMPRSS2 (show TMPRSS2 Proteins) and, therefore, can be activated in a wide range of tissues what may affect virus spread, tissue tropism and pathogenicity.
TMPRSS2 (show TMPRSS2 Proteins) and HAT (show MGEA5 Proteins) are expressed by important influenza and SARS (show SARS Proteins)-coronavirus target cells and could thus support viral spread in the human host.
results suggest that HAI-1 functions as a physiological regulator of HAT by inhibiting its protease activity and proteolytic activation in airway epithelium.(HAT)
HAT cleaves proMSP at the physiological activation site
Human HAT cleaved severe acute respiratory syndrome coronavirus spike protein at R667, as determined by mutagenesis and mass spectrometry.
HAT (show MGEA5 Proteins) regulates cellular functions of human bronchial epithelial cells via activation of protease-activated receptor-2 (show F2RL1 Proteins).
HAT (show MGEA5 Proteins) might promote PAR-2 (show F2RL1 Proteins)-mediated IL-8 (show IL8 Proteins) production to accumulate inflammatory cells in the epidermal layer of psoriasis.
results indicate that HAT stimulates fibroblast proliferation in bronchial airways through a PAR-2-dependent MEK-MAPK mediated pathway and that HAT is linked to airway processes involving fibroblasts
HAT (show MGEA5 Proteins) induces amphiregulin (show AREG Proteins) production through the PAR-2 (show F2RL1 Proteins) mediated ERK (show EPHB2 Proteins) pathway, and then causes amphiregulin (show AREG Proteins) release by a TACE (show ADAM17 Proteins)-dependent mechanism
This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
bifunctional protein NCOAT
, meningioma-expressed antigen 5
, nuclear cytoplasmic O-GlcNAcase and acetyltransferase
, airway trypsin like protease
, airway trypsin-like protease
, transmembrane protease serine 11D
, adrenal secretory serine protease
, airway spesific trypsin-like protease
, transmembrane serine protease 11D