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In summary, cardiac expression of CRFR1 (show CRHR1 ELISA Kits), CRF (show CRH ELISA Kits), and Ucn3 genes is elevated in heart failure and may contribute to the activation of the CRF (show CRH ELISA Kits)/Ucn (show UCN ELISA Kits) system in these patients.
circulating levels elevated and positively correlated with C-reactive protein (show CRP ELISA Kits) in polycystic ovary syndrome
results show that activation of CRH (show CRH ELISA Kits) receptors by CRH (show CRH ELISA Kits) ligands stimulates VEGF-A (show VEGFA ELISA Kits) expression in intestinal epithelial cells through the cAMP/CREB (show CREB1 ELISA Kits) pathway
The paracrine actions of Ucn3 activate a negative feedback loop that promotes somatostatin (show SST ELISA Kits) release to ensure the timely reduction of insulin (show INS ELISA Kits) secretion upon normalization of plasma glucose.
The molecular modifications of urocortin 3[36-38] led to an improved understanding of the relationship between molecular structure and biological activity of this peptide, could be further tested for possible clinical treatment of depression
Data suggest that UCN3 expression can serve as a late stage maturation/differentiation marker in beta-cells during pancreogenesis. [REVIEW]
SCP (show RAG1AP1 ELISA Kits) inhibits a subpopulation of PVN neurons, especially OTergic magnocellular neurons, by enhancing the activity of GIRK channels via CRF-R2 (show CRHR2 ELISA Kits)
study showed that Ucn2 (show UTS2 ELISA Kits) and Ucn3 differentially regulate the LPS (show IRF6 ELISA Kits)-induced TNF-alpha (show TNF ELISA Kits) and IL-10 (show IL10 ELISA Kits) expression and secretion in trophoblast explants acting through CRH-R2 (show CRHR2 ELISA Kits). Ucn3 has an anti-inflammatory effect.
These data suggest a possible involvement of urocortin 2 (show UCN2 ELISA Kits) and Ucn 3 in the mechanisms of endometriosis.
Confirm the anti-inflammatory function of VIP (show Vip ELISA Kits), through the modulation of the expression of CRF (show CRH ELISA Kits) system that impacts in a reduction of mediators with inflammatory/destructive functions.
Ucn3 KO mice displayed significantly increased ethanol intake and preference compared with WT. There were no long-term effects of chronic pain on alcohol drinking behavior, regardless of genotype.
This study aims to investigate the cellular localization of CRF (show CRH ELISA Kits) and UCNs in the ileum and to explore whether and how this cellular expression is altered in conditions of intestinal Schistosoma mansoni-induced inflammation.
UCN3 expression enhances glucose disposal and signalling in muscle by an autocrine/paracrine mechanism that is separate from its pro-hypertrophic effects.
Leptin (show LEP ELISA Kits) regulates corticotropin-releasing factor (show CRH ELISA Kits) and urocortin 2 (show UTS2 ELISA Kits)/3 mRNA in hypothalamic neurons.
Urocortin 3 acting on CRFR2 (show CRHR2 ELISA Kits) in skeletal muscle of Ucn3(+) mice results in a metabolic phenotype, with lean body composition and protection against diet-induced obesity and hyperglycaemia.
In this study, the intracerebroventricularly administered Ucn3 exerted an inhibitory effect on food intake, although the potency for decreasing food intake differed with the experimental conditions.
The results of this study suggested a novel role for UCN3 and CRH-R2 (show CRHR2 ELISA Kits) related to the processing of social cues and to the establishment of social memories.
demonstrate the involvement of the hypothalamic neuropeptide Urocortin-3 in modulating septal and hypothalamic nuclei responsible for anxiety-like behaviors and metabolic functions, respectively.
pancreatic Ucn III acting through CRFR2 (show CRHR2 ELISA Kits) is involved in the local regulation of glucagon (show GCG ELISA Kits) and insulin (show INS ELISA Kits) secretion.
This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.
, urocortin 3
, prepro-urocortin 3
, ucn III
, urocortin III
, Urocortin II
, Urocortin III
, urocortin 3 (stresscopin)