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anti-Mouse (Murine) PTTG1IP Antibodies:
anti-Rat (Rattus) PTTG1IP Antibodies:
anti-Human PTTG1IP Antibodies:
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protooncogene PBF is a negative regulator of p53 (show TP53 Antibodies) function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 (show TP53 Antibodies) mutations are rare compared with other tumor types
Findings indicate that PBF and PTTG (show PTTG1 Antibodies) have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome.
Unique role for PBF in regulating CTTN (show CTTN Antibodies) function to promote endocrine cell invasion and migration.
these results demonstrate an emerging role for PBF in colorectal tumorigenesis through regulating p53 (show TP53 Antibodies) activity, with implications for PBF as a prognostic indicator for invasive tumors.
These findings indicate that miR (show MLXIP Antibodies)-584 suppresses glioma cell growth by negatively regulating the expression of PTTG1IP, suggesting that miR (show MLXIP Antibodies)-584 has a tumor suppressive role in human glioma pathogenesis.
Data from mutant recombinant proteins suggest that proto-oncogene (show RAB1A PLURAL_@12224@) PBF is a phosphoprotein and highlight importance of tyrosine residue Y174 in both endocytosis of PBF and its interaction/co-localization with NIS/SLC5A5 (sodium-iodide symporter (show SLC5A5 PLURAL_@12224@)).
PBF expression may be a promising biomarker for prognostic and therapeutic purposes in papillary thyroid carcinoma patients.
Authors identified pituitary tumor-transforming gene 1 (PTTG1 (show PTTG1 Antibodies)) binding factor (PBF) as a target of miR (show MLXIP Antibodies)-122 and demonstrated that hepatitis B virus replication causes an obvious increase in PBF levels.
The present study provides the first epidemiological evidence that functional regulatory variants of PTTG1IP were associated with the risk of ER-positive breast cancer, further supporting its relevance as one proto-oncogene (show RAB1A Antibodies) in breast cancer.
overexpression of PBF causes thyroid cell proliferation, macrofollicular lesions, and hyperplasia, as well as repression of the critical therapeutic route for radioiodide uptake
The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1.
, PTTG-binding factor
, pituitary tumor-transforming gene 1 protein-interacting protein
, pituitary tumor-transforming gene protein-binding factor