Caspase 1 (CASP1) (AA 120-269), (partial) protein (GST tag)

Details for Product No. ABIN1046768
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Protein Name
Synonyms CG5370, DCP-1, DCP1, Dcp1, Dmel\\CG5370, ccp1, dcp-1, dcp1, l(2)01862, l(2)02132, Ice, ICE, Il1bc, IL1BC, P45, CASP1
Protein Characteristics
AA 120-269, partial
Origin
Human
(19), (8), (5), (3), (2), (1), (1), (1)
Source
Escherichia coli (E. coli)
(29), (5), (3), (2)
Protein Type Recombinant
Purification tag / Conjugate
This Caspase 1 protein is labelled with GST tag.
Application
ELISA
Pubmed 3 references available
Quantity 50 μg
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Sequence NPAMPTSSGS EGNVKLCSLE EAQRIWKQKS AEIYPIMDKS SRTRLALIIC NEEFDSIPRR TGAEVDITGM TMLLQNLGYS VDVKKNLTAS DMTTELEAFA HRPEHKTSDS TFLVFMSHGI REGICGKKHS EQVPDILQLN AIFNMLNTKN
Characteristics Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
Purity 90 %
Alternative Name Caspase-1 protein
Background Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Molecular Weight 44.2 kD
UniProt P29466
Comment

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Restrictions For Research Use only
Format Lyophilized
Concentration 0.2-2 mg/mL
Buffer Tris-based buffer, 50 % glycerol
Handling Advice Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
Storage -20 °C
Storage Comment Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
Supplier Images
Caspase 1 (CASP1) (AA 120-269), (partial) protein (GST tag) Caspase 1 (CASP1) (AA 120-269), (partial) protein (GST tag)
Background publications Miller, Ayala, Egger et al.: "Purification and characterization of active human interleukin-1 beta-converting enzyme from THP.1 monocytic cells." in: The Journal of biological chemistry, Vol. 268, Issue 24, pp. 18062-9, 1993 (PubMed).

Thornberry, Bull, Calaycay et al.: "A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes." in: Nature, Vol. 356, Issue 6372, pp. 768-74, 1992 (PubMed).

Cerretti, Kozlosky, Mosley et al.: "Molecular cloning of the interleukin-1 beta converting enzyme." in: Science (New York, N.Y.), Vol. 256, Issue 5053, pp. 97-100, 1992 (PubMed).

Validation Images
Catalog No. ABIN1046768
242.00 $
Plus shipping costs $45.00
Quantity
Price
50 μg
242.00 $
Plus shipping costs $45.00

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