DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1) (AA 4-198), (partial) protein (GST tag)

Details for Product No. ABIN1046947
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Protein Name
Synonyms fb26e10, zgc:56003, zgc:77337, wu:fb26e10, DRAP1, 2310074H19Rik, NC2-alpha
Protein Characteristics
AA 4-198, partial
Origin
Human
(6), (1), (1)
Source
Escherichia coli (E. coli)
(4), (2), (2)
Protein Type Recombinant
Purification tag / Conjugate
GST tag
Application
SDS-PAGE (SDS), ELISA
Pubmed 5 references available
Quantity 200 µg
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Catalog No. ABIN1046947
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Sequence KKKKYNARFP PARIKKIMQT DEEIGKVAAA VPVIISRALE LFLESLLKKA CQVTQSRNAK TMTTSHLKQC IELEQQFDFL KDLVASVPDM QGDGEDNHMD GDKGARRGRK PGSGGRKNGG MGTKSKDKKL SGTDSEQEDE SEDTDTDGEE ETSQPPPQAS HPSAHFQSPP TPFLPFASTL PLPPAPPGPS APDEE
Characteristics The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Ref.1 Ref.2
Purity 90 %
Alternative Name Dr1-associated corepressor
Background Synonyms: Dr1-associated protein 1,Negative co-factor 2-alpha,NC2-alpha
Molecular Weight 48.6 kD
UniProt Q14919
Comment

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Restrictions For Research Use only
Buffer PBS buffer, 20mM GSH
Storage -20 °C
Product cited in: Mermelstein, Yeung, Cao et al.: "Requirement of a corepressor for Dr1-mediated repression of transcription." in: Genes & development, Vol. 10, Issue 8, pp. 1033-48, 1996 (PubMed).

Goppelt, Stelzer, Lottspeich et al.: "A mechanism for repression of class II gene transcription through specific binding of NC2 to TBP-promoter complexes via heterodimeric histone fold domains." in: The EMBO journal, Vol. 15, Issue 12, pp. 3105-16, 1996 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Klejman, Pereira, van Zeeburg et al.: "NC2alpha interacts with BTAF1 and stimulates its ATP-dependent association with TATA-binding protein." in: Molecular and cellular biology, Vol. 24, Issue 22, pp. 10072-82, 2004 (PubMed).

Burkard, Planyavsky, Kaupe et al.: "Initial characterization of the human central proteome." in: BMC systems biology, Vol. 5, pp. 17, 2011 (PubMed).

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