ACVR2B Protein (AA 19-137) (His tag)
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- Target See all ACVR2B Proteins
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 19-137
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This ACVR2B protein is labelled with His tag.
- Sequence
- AA 19-137
- Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.5 kDa. The protein migrates as 25-32 kDa under reducing (R) condition (SDS-PAGE).
- Purity
- >90 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product ACVR2B Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: 4-8°C for 1 year in lyophilized state 4-8°C for 1 month under sterile conditions after reconstitution -20°C to -70°C for 3 months under sterile conditions after reconstitution
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- Target
- ACVR2B (Activin A Receptor, Type IIB (ACVR2B))
- Alternative Name
- ACVR2B (ACVR2B Products)
- Synonyms
- ACVR2B Protein, XAR1 Protein, actr-iib Protein, actriib Protein, ACTRIIB Protein, ActR-IIB Protein, HTX4 Protein, ActRIIB Protein, actr2b Protein, actrIIb Protein, wu:fj97d11 Protein, activin A receptor type 2B Protein, activin A receptor type 2B L homeolog Protein, activin A receptor type 2Ba Protein, activin receptor IIB Protein, ACVR2B Protein, acvr2b Protein, acvr2b.L Protein, Acvr2b Protein, acvr2ba Protein
- Background
- Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. Defects in ACVR2B are the cause of visceral heterotaxy autosomal type 4 (HTX4).
- Molecular Weight
- 14.5 kDa
- NCBI Accession
- NP_001097
- Pathways
- Hormone Transport, Cancer Immune Checkpoints
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