Interferon gamma Protein (IFNG) (AA 24-166)
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- Target See all Interferon gamma (IFNG) Proteins
- Interferon gamma (IFNG)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 24-166
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Origin
- Human
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Source
- HEK-293 Cells
- Brand
- ActiveMax®
- Sequence
- AA 24-166
- Characteristics
- This protein carries no "tag". The protein has a calculated MW of 16.8 kDa. The protein migrates as 17 kDa,20 kDa and 24 kDa under reducing (R) condition (SDS-PAGE) due to different glycosylation.
- Purity
- >90 % as determined by SDS-PAGE.
- Sterility
- 0.22 μm filtered
- Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product IFNG Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handling Advice
- Please avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C-8 °C), After reconstitution under sterile conditions for 1 month (4 °C-8 °C) or 3 months (-20 °C to -70 °C).
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Diffusion of cytokines in live lymph node tissue using microfluidic integrated optical imaging." in: Analytica chimica acta, Vol. 1000, pp. 205-213, (2018) (PubMed).
: "Improved therapeutic efficacy of mammalian expressed-recombinant interferon gamma against ovarian cancer cells." in: Experimental cell research, Vol. 359, Issue 1, pp. 20-29, (2017) (PubMed).
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Diffusion of cytokines in live lymph node tissue using microfluidic integrated optical imaging." in: Analytica chimica acta, Vol. 1000, pp. 205-213, (2018) (PubMed).
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- Target
- Interferon gamma (IFNG)
- Alternative Name
- IFN-gamma (IFNG Products)
- Synonyms
- IFG Protein, IFI Protein, IFN-g Protein, Ifg Protein, IFNG2 Protein, IFN-gamma Protein, IFN-G Protein, IFNG Protein, IFNgamma Protein, TCRalpha Protein, INF-G Protein, ifng Protein, interferon gamma Protein, interferon, gamma 1-2 Protein, IFNG Protein, Ifng Protein, ifng1-2 Protein
- Background
- Interferon-gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN-γ belongs. IFN-gamma has been used in a wide variety of clinical indications. Interferon-gamma (IFNgamma) is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFNG that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.
- Molecular Weight
- 16.8 kDa
- Pathways
- Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy
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