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EIF2AK2 Protein (Transcript Variant 2) (Myc-DYKDDDDK Tag)

EIF2AK2 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2720058
  • Target See all EIF2AK2 Proteins
    EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))
    Protein Type
    Recombinant
    Protein Characteristics
    Transcript Variant 2
    Origin
    • 4
    • 2
    • 1
    Human
    Source
    • 5
    • 1
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This EIF2AK2 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human EIF2AK2 / PKR (transcript variant 2) protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product EIF2AK2 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Target
    EIF2AK2 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 2 (EIF2AK2))
    Alternative Name
    Eif2ak2,pkr (EIF2AK2 Products)
    Synonyms
    PKR Protein, pkr Protein, EIF2AK2 Protein, DKFZp469K1934 Protein, EIF2AK1 Protein, PRKR Protein, 2310047A08Rik Protein, 4732414G15Rik Protein, AI467567 Protein, AI747578 Protein, Pkr Protein, Prkr Protein, Tik Protein, eukaryotic translation initiation factor 2 alpha kinase 2 Protein, eukaryotic translation initiation factor 2-alpha kinase 2 Protein, EIF2AK2 Protein, eif2ak2 Protein, Eif2ak2 Protein
    Background
    The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene.
    Molecular Weight
    61.9 kDa
    NCBI Accession
    NP_001129123
    Pathways
    DNA Damage Repair, ER-Nucleus Signaling, Hepatitis C
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