GSK3 alpha Protein (Myc-DYKDDDDK Tag)
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- Target See all GSK3 alpha (GSK3a) Proteins
- GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This GSK3 alpha protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human GSK3 alpha protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product GSK3a Protein
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?" in: ACS chemical neuroscience, Vol. 7, Issue 2, pp. 161-70, (2016) (PubMed).
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Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?" in: ACS chemical neuroscience, Vol. 7, Issue 2, pp. 161-70, (2016) (PubMed).
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- Target
- GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
- Alternative Name
- Gsk3 alpha (GSK3a Products)
- Synonyms
- 2700086H06Rik Protein, GSK3A Protein, GSK-3[a] Protein, GSK-3[b] Protein, GSK3 Protein, gsk3a Protein, xgsk3 Protein, glycogen synthase kinase 3 alpha Protein, glycogen synthase kinase 3 alpha b Protein, glycogen synthase kinase 3 alpha S homeolog Protein, GSK3A Protein, Gsk3a Protein, gsk3a Protein, gsk3ab Protein, gsk3a.S Protein, Bm1_31380 Protein
- Background
- This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.
- Molecular Weight
- 50.8 kDa
- NCBI Accession
- NP_063937
- Pathways
- PI3K-Akt Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, Warburg Effect
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