NR1H3 Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
(1 reference)-
- Target See all NR1H3 Proteins
- NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
- Protein Type
- Recombinant
- Protein Characteristics
- Transcript Variant 1
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This NR1H3 protein is labelled with Myc-DYKDDDDK Tag.
- Application
- Antibody Production (AbP), Standard (STD)
- Characteristics
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- Recombinant human NR1H3 (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- Purity
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product NR1H3 Protein
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Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) (AA 1-387) protein (GST tag)
NR1H3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) (AA 1-447) protein (Strep Tag)Crystallography grade NR1H3 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) (AA 1-445) protein (Strep Tag)Crystallography grade NR1H3 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3) (AA 1-402), (Isoform 3) protein (His-SUMO Tag)NR1H3 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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- Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - Comment
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The tag is located at the C-terminal.
- Restrictions
- For Research Use only
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- Concentration
- 50 μg/mL
- Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- Storage
- -80 °C
- Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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: "Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 29, pp. 8182-7, (2016) (PubMed).
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: "Insulin induction of SREBP-1c in rodent liver requires LXRα-C/EBPβ complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 29, pp. 8182-7, (2016) (PubMed).
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- Target
- NR1H3 (Nuclear Receptor Subfamily 1, Group H, Member 3 (NR1H3))
- Alternative Name
- Nr1h3 (NR1H3 Products)
- Synonyms
- NR1H3 Protein, LXR-a Protein, LXRA Protein, RLD-1 Protein, AU018371 Protein, LXR Protein, RLD1 Protein, Unr1 Protein, LXRalpha Protein, LXR-alpha Protein, im:7141239 Protein, wu:fd59b01 Protein, zgc:113339 Protein, zgc:158542 Protein, nuclear receptor subfamily 1 group H member 3 Protein, nuclear receptor subfamily 1, group H, member 3 Protein, NR1H3 Protein, nr1h3 Protein, Nr1h3 Protein
- Background
- The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
- 50.2 kDa
- NCBI Accession
- NP_005684
- Pathways
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Nuclear Hormone Receptor Binding, Cellular Response to Molecule of Bacterial Origin, Hepatitis C
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